Li, Q., Hariharan, I.K., Chen, F., Huang, Y., Fischer, J.A. (1997). Genetic interactions with rap1 and ras1 reveal a second function for the fat facets deubiquitinating enzyme in Drosophila eye development.  Proc. Natl. Acad. Sci. U.S.A. 94(23): 12515--12520.

FBrf0099363

Research paper

The Drosophila fat facets gene encodes a deubiquitinating enzyme that regulates a cell communication pathway essential very early in eye development, prior to facet assembly, to limit the number of photoreceptor cells in each facet of the compound eye to eight. The Fat facets protein facilitates the production of a signal in cells outside the developing facets that inhibits neural development of particular facet precursor cells. Novel gain-of-function mutations in the Drosophila Rap1 and Ras1 genes are described herein that interact genetically with fat facets mutations. Analysis of these genetic interactions reveals that Fat facets has an additional function later in eye development involving Rap1 and Ras1 proteins. Moreover, the results suggest that undifferentiated cells outside the facet continue to influence facet assembly later in eye development.

PMC25022 (PMC) (EuropePMC)