FlyBase Allele Report: Dmel\ush[rev24]

General Information

Symbol

Dmel\ush^rev24

Species

D. melanogaster

Name

FlyBase ID

FBal0082096

Feature type

allele

Associated gene

Dmel\ush

Associated Insertion(s)

Carried in Construct

Also Known As

ush^r24

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Gao et al., 2009, Cubadda et al., 1997)

Mutagen

P-element activity

(Cubadda et al., 1997)

Progenitor genotype

ush¹⁵¹³

(Cubadda et al., 1997)

Cytology

Description

Imprecise excision of the P{lacZ} element, deleting DNA starting from the site of the P{lacZ} element insertion and extending distally.

(Cubadda et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | third instar larval stage (with ush^VX22)

(Gao et al., 2009)

hyperplasia | third instar larval stage (with ush^VX22)

(Gao et al., 2009, Sorrentino et al., 2007)

increased cell number | third instar larval stage (with ush^VX22)

(Sorrentino et al., 2007)

viable

(Cubadda et al., 1997)

visible | recessive

(Cubadda et al., 1997)

Phenotype Manifest In

dorsocentral bristle

(Cubadda et al., 1997)

dorsocentral bristle & axon

(Usui-Ishihara and Simpson, 2005)

dorsocentral bristle | cell non-autonomous | somatic clone

(Cubadda et al., 1997)

embryonic/larval lymph gland (with ush^VX22)

(Tokusumi et al., 2010)

embryonic/larval lymph gland | second instar larval stage (with ush^VX22)

(Sorrentino et al., 2007)

embryonic/larval lymph gland | third instar larval stage (with ush^VX22)

(Gao et al., 2009)

embryonic/larval plasmatocyte | third instar larval stage (with ush^VX22)

(Gao et al., 2009)

hemocyte | third instar larval stage (with ush^VX22)

(Sorrentino et al., 2007)

lamellocyte (with ush^VX22)

(Tokusumi et al., 2010)

lamellocyte | third instar larval stage (with ush^VX22)

(Gao et al., 2009, Sorrentino et al., 2007)

postocellar bristle

(Cubadda et al., 1997)

scutellar bristle

(Cubadda et al., 1997)

Detailed Description

Statement

Reference

ush^VX22/ush^rev24 mutant larvae exhibit an over-production of lamellocytes in the lymph glands.

(Tokusumi et al., 2010)

ush^VX22/ush^rev24 third instar larval lymph glands exhibit hyperplasia. Lymph glands are on average two times larger in size compared to ush^VX22/+ larvae, and three times larger in size compared to wildtype controls. Plasmatocyte and crystal cell numbers are decreased in ush^VX22/ush^rev24 lymph glands. A substantial increase in lamellocyte differentiation is observed.

(Gao et al., 2009)

Lymph glands from ush^VX22/ush^rev24 second instar larvae have a comparable size to control glands. In third instar larvae, lymph glands are extremely hypertrophic compared to controls. There is a four-fold increase in circulating haemocytes, including a large lamellocyte population which comprises about 20% of all circulating haemocytes.

(Sorrentino et al., 2007)

Mutants do not exhibit ectopic dorsocentral (DC) bristles. the anterior and posterior DCs (aDC, pDC) are located at wild-type locations. However projection of these bristles are found to display differences from wild-type. The arborization appears more compact and dense with a greater number of side branches. Additional side branches are seen both at the point of entry into the thoracic ganglion and after crossing the midline on the anterior, main and posterior cross branches. In addition there are many varicosities, not usually seen in macrochaetes.

(Usui-Ishihara and Simpson, 2005)

ush^rev24/Df(2L)ush^rev18 flies have an excess of dorsocentral and scutellar bristles, and show a loss of postvertical bristles. Dorsocentral bristles produced by wild-type cells at the border of homozygous clones in the dorsocentral region are nearly all displaced from their normal positions.

(Cubadda et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

ush^R24

(Lenz et al., 2021, Baldeosingh et al., 2018, Gao et al., 2016)

ush^Rev24

(Moussalem et al., 2021, Fromental-Ramain et al., 2010, Usui-Ishihara and Simpson, 2005)

ush^r24

(Sorrentino, 2010, Tokusumi et al., 2010, Sorrentino et al., 2007)

ush^rev24

(Fromental-Ramain et al., 2010, Gao et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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