FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\shn3.3
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General Information
Symbol
Dmel\shn3.3
Species
D. melanogaster
Name
FlyBase ID
FBal0082260
Feature type
allele
Associated gene
Dmel\shn
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Matunis et al., 1997)
Mutagen
ethyl methanesulfonate
(Matunis et al., 1997)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous somatic clones induced during mid to late third larval instar stage are recovered at a significantly higher frequency than those induced earlier.

      (Torres-Vazquez et al., 2000)

      Somatic clones in the male testis produce overproliferating germ cells, a cyst contains many more than 16 cells that are much smaller than wild type. Germ line clones do not show overproliferation of the germ cells. Cysts of overproliferating germ cells is surrounded by the normal complement of cyst cells: cyst cells are not deleteriously affected by loss of shn. Incomplete cytokinesis is occurring in many, if not all, of the overproliferating germ cells within a cyst. The overproliferating germ cells exhibit spermatogonial rather than stem cell behaviour. Mutants exhibit visceral mesoderm and cuticle defects, cells of the visceral mesoderm fail to fuse and defects in dorsal closure lead to a curved appearance of the cuticle.

      (Matunis et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      shn3.3/shn[+] is a suppressor of visible phenotype of Scer\GAL4A9, gbbUAS.cKa

      (Bangi and Wharton, 2006)

      shn3.3/shn[+] is a suppressor of visible phenotype of Scer\GAL4A9, dppUAS.cUa

      (Bangi and Wharton, 2006)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      shn3.3/shn[+] is a suppressor of wing vein phenotype of Scer\GAL4A9, gbbUAS.cKa

      (Bangi and Wharton, 2006)

      shn3.3/shn[+] is a suppressor of wing phenotype of Scer\GAL4A9, dppUAS.cUa

      (Bangi and Wharton, 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      shn3.3
      (Bangi and Wharton, 2006)
      shn3.3J
      (Torres-Vazquez et al., 2000)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)