FlyBase Allele Report: Dmel\dpp[UAS.cUa]

(Bangi and Wharton, 2006, Vilmos et al., 2005, Ross et al., 2001, Yu et al., 2000, Haerry et al., 1998, Nguyen et al., 1998, Jackson et al., 1997)

wing, with Scer\GAL4^unspecified

(Hoodless et al., 1996)

wing cell, with Scer\GAL4^A9

(Yu et al., 2000, Haerry et al., 1998)

wing disc, with Scer\GAL4^A9

(Haerry et al., 1998)

wing disc, with Scer\GAL4^ap-md544

(Adachi-Yamada and O'Connor, 2002)

wing vein, with Scer\GAL4^A9

(Ross et al., 2001)

wing vein | ectopic, with Scer\GAL4^A9

(Yu et al., 2000)

Detailed Description

Statement

Reference

Adulthood-only expression of dpp^UAS.cUa under the combined control of Scer\GAL4^esg.PU and Gal80[ts] (induced by temperature shift from 18[o]C to 29[o]C) does not affect the number of intestinal progenitors (i.e. esg-positive cells) in the adult posterior midgut, as compared to controls.

(Ma et al., 2019)

Forced expression of dpp^Scer\UAS.cUa driven by Scer\GAL4^ey.PU appears to initiate ectopic eye formation at the anterior margin of the eye field. Often the result is the production of two compound eyes being generated from a single retinal field.

(Salzer et al., 2010)

63-day old germaria expressing dpp^Scer\UAS.cUa via Scer\GAL4^hh.PU (with expression controlled via 'UAS-gal80[ts]' and temperature) have significantly fewer germline cell stems and cap cells compared to controls.

(Pan et al., 2007)

Expression of dpp^Scer\UAS.cHa under the control of Scer\GAL4^A9 causes a variable phenotype in the wing, ranging from a little ectopic wing vein material to blistered wings.

(Bangi and Wharton, 2006)

Females in which expression of dpp^Scer\UAS.cUa under the control of Scer\GAL4^bab1-Gal4 has been restricted to the adult stage using Scer\GAL80^ts.αTub84B (animals are shifted to the restrictive temperature of 31[o]C when adult) show a strong germline stem cell tumour phenotype in the ovary after 3 days of dpp^Scer\UAS.cUa expression.

(Bolivar et al., 2006)

Expression of dpp^Scer\UAS.cUa under the control of Scer\GAL4^nos.PG results in ectopic germline stem cells in the testis.

(Singh et al., 2006)

Overexpression of dpp^Scer\UAS.cHa, under the regulation of Scer\GAL4^A9, can result in wing disruption.

(Vilmos et al., 2005)

When dpp^Scer\UAS.cHa is driven by Scer\GAL4^ap-md544 overgrowth of wing disc is seen.

(Adachi-Yamada and O'Connor, 2002)

Misexpression driven by Scer\GAL4^55B does not generate any eggshell defects, though embryonic DV patterning is affected in that the embryos are dorsalized.

(Araujo and Bier, 2000)

Expression of dpp^Scer\UAS.cHa under the control of Scer\GAL4^A9 produces broadened wings consisting of solid veins.

(Yu et al., 2000)

Flies expressing dpp^Scer\UAS.cHa under the control of Scer\GAL4^A9 have small wings which are blistered due to lack of adhesion of the dorsal and ventral compartments. Intervein cells express vein-specific hairs and the marginal triple row bristles are transformed into the oversized double row bristles normally seen at more distal positions along the wing margin. The wings are darkly pigmented. Larvae expressing dpp^Scer\UAS.cHa under the control of Scer\GAL4^A9 show overgrowth of the wing discs.

(Haerry et al., 1998)

Flies expressing dpp^Scer\UAS.cHa under the control of Scer\GAL4^A9 have small, blistered wings that have pigmentation and hairs typical of vein tissue.

(Nguyen et al., 1998)

Causes wing margin defects when expressed using Scer\GAL4^A9.

(Jackson et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^Act5C.PU, dpp^UAS.cUa has increased cell death | embryonic stage phenotype, suppressible by Scer\GAL4^Act5C.PU/Tak1^K46R.UAS

(Yang and Su, 2011)

Scer\GAL4^Act5C.PU, dpp^UAS.cUa has increased cell death | embryonic stage phenotype, suppressible by Scer\GAL4^Act5C.PU/bsk^DN.UAS.cUa

(Yang and Su, 2011)

Scer\GAL4^Act5C.PU, dpp^UAS.cUa has increased cell death | embryonic stage phenotype, suppressible by Scer\GAL4^Act5C.PU/p53^DN.UAS.cUa

(Yang and Su, 2011)

Scer\GAL4^Act5C.PU, dpp^UAS.cUa has increased cell death | embryonic stage phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^Act5C.PU

(Yang and Su, 2011)

Scer\GAL4^A9, dpp^UAS.cUa has visible phenotype, suppressible by Scer\GAL4^A9/cv-2^UAS.cSa

(Serpe et al., 2008)

Scer\GAL4^A9, dpp^UAS.cUa has visible phenotype, suppressible by tkv⁷/tkv[+]

(Bangi and Wharton, 2006)

Scer\GAL4^A9, dpp^UAS.cUa has visible phenotype, suppressible | partially by sax⁴/sax[+]

(Bangi and Wharton, 2006)

Scer\GAL4^A9, dpp^UAS.cUa has visible phenotype, suppressible by tkv⁵/tkv[+]

(Bangi and Wharton, 2006)

Scer\GAL4^A9, dpp^UAS.cUa has visible phenotype, suppressible by tkv⁸/tkv[+]

(Bangi and Wharton, 2006)

Scer\GAL4^A9, dpp^UAS.cUa has visible phenotype, suppressible by Mad¹²/Mad[+]

(Bangi and Wharton, 2006)

Scer\GAL4^A9, dpp^UAS.cUa has visible phenotype, suppressible by Med[+]/Med¹

(Bangi and Wharton, 2006)

Scer\GAL4^A9, dpp^UAS.cUa has visible phenotype, suppressible by shn^3.3/shn[+]

(Bangi and Wharton, 2006)

Scer\GAL4^A9, dpp^UAS.cUa has visible phenotype, suppressible by Df(2R)H23/+

(Bangi and Wharton, 2006)

Scer\GAL4^A9, dpp^UAS.cUa has visible phenotype, suppressible | partially by Scer\GAL4^A9/sog^UAS.cYa/tsg^UAS.cYa

(Ross et al., 2001)

Scer\GAL4^A9, dpp^UAS.cUa, sog^UAS.cYa has visible phenotype, suppressible by Scer\GAL4^A9/tsg^UAS.cYa

(Ross et al., 2001)

Scer\GAL4^A9, dpp^UAS.cUa, tsg^UAS.cYa has visible phenotype, suppressible by Scer\GAL4^A9/sog^UAS.cYa

(Ross et al., 2001)

Scer\GAL4^A9, dpp^UAS.cUa has visible phenotype, suppressible | partially by Scer\GAL4^A9/sog^{supersog1.UAS}

(Yu et al., 2000)

Scer\GAL4^A9, dpp^UAS.cUa has visible phenotype, suppressible | partially by Xlae\nog.L^UAS.cYa/Scer\GAL4^A9

(Yu et al., 2000)

Scer\GAL4^A9, dpp^UAS.cUa has visible phenotype, suppressible | partially by Scer\GAL4^A9/tkv^1ΔGSK.UAS

(Haerry et al., 1998, Nguyen et al., 1998)

Scer\GAL4^A9, dpp^UAS.cUa has visible phenotype, suppressible by dally^ΔP-527/dally[+]

(Jackson et al., 1997)

NOT suppressed by

Statement

Reference

Scer\GAL4^A9, dpp^UAS.cUa has visible phenotype, non-suppressible by Scer\GAL4^A9/tsg^UAS.cYa

(Ross et al., 2001)

Scer\GAL4^A9, dpp^UAS.cUa has visible phenotype, non-suppressible by Scer\GAL4^A9/sog^UAS.cYa

(Ross et al., 2001, Nguyen et al., 1998)

Scer\GAL4^A9, dpp^UAS.cUa has visible phenotype, non-suppressible by Scer\GAL4^A9/sax^ΔI.UAS

(Haerry et al., 1998, Nguyen et al., 1998)

NOT Enhancer of

Statement

Reference

Scer\GAL4^Act5C.PU/dpp^UAS.cUa is a non-enhancer of decreased cell death | embryonic stage phenotype of Scer\GAL4^Act5C.PU, Tak1^K46R.UAS

(Yang and Su, 2011)

Suppressor of

Statement

Reference

dpp^UAS.cUa/Scer\GAL4^esg.PU is a suppressor of increased cell number | adult stage phenotype of Scer\GAL4^esg.PU, botv^GD2083

(Ma et al., 2019)

Scer\GAL4^ptc-559.1/dpp^UAS.cUa is a suppressor | partially of visible phenotype of Scer\GAL4^ptc-559.1, gbb^UAS.cKa

(Khalsa et al., 1998)

Scer\GAL4^71B/dpp^UAS.cUa is a suppressor | partially of visible phenotype of Scer\GAL4^71B, gbb^UAS.cKa

(Khalsa et al., 1998)

Scer\GAL4^A9/dpp^UAS.cUa is a suppressor | partially of visible phenotype of Scer\GAL4^A9, gbb^UAS.cKa

(Khalsa et al., 1998)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Act5C.PU/dpp^UAS.cUa is a non-suppressor of decreased cell death | embryonic stage phenotype of Scer\GAL4^Act5C.PU, Tak1^K46R.UAS

(Yang and Su, 2011)

Other

Statement

Reference

Scer\GAL4^A9, dpp^UAS.cUa, sog^UAS.cYa has visible phenotype

(Ross et al., 2001)

Scer\GAL4^A9, dpp^UAS.cUa, tsg^UAS.cYa has visible phenotype

(Ross et al., 2001)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^A9, dpp^UAS.cUa has wing phenotype, suppressible by Scer\GAL4^A9/cv-2^UAS.cSa

(Serpe et al., 2008)

Scer\GAL4^A9, dpp^UAS.cUa has wing phenotype, suppressible by tkv⁷/tkv[+]

(Bangi and Wharton, 2006)

Scer\GAL4^A9, dpp^UAS.cUa has wing phenotype, suppressible | partially by sax⁴/sax[+]

(Bangi and Wharton, 2006)

Scer\GAL4^A9, dpp^UAS.cUa has wing phenotype, suppressible by tkv⁵/tkv[+]

(Bangi and Wharton, 2006)

Scer\GAL4^A9, dpp^UAS.cUa has wing phenotype, suppressible by tkv⁸/tkv[+]

(Bangi and Wharton, 2006)

Scer\GAL4^A9, dpp^UAS.cUa has wing phenotype, suppressible by Mad¹²/Mad[+]

(Bangi and Wharton, 2006)

Scer\GAL4^A9, dpp^UAS.cUa has wing phenotype, suppressible by Med[+]/Med¹

(Bangi and Wharton, 2006)

Scer\GAL4^A9, dpp^UAS.cUa has wing phenotype, suppressible by shn^3.3/shn[+]

(Bangi and Wharton, 2006)

Scer\GAL4^A9, dpp^UAS.cUa has wing phenotype, suppressible by Df(2R)H23/+

(Bangi and Wharton, 2006)

Scer\GAL4^nanos.PG, dpp^UAS.cUa has male germline stem cell | increased number phenotype, suppressible by BHD^RNAi.Sym.UAS, Scer\GAL4^nanos.PG

(Singh et al., 2006)

Scer\GAL4^A9, dpp^UAS.cUa has wing vein phenotype, suppressible | partially by Scer\GAL4^A9/sog^UAS.cYa/tsg^UAS.cYa

(Ross et al., 2001)

Scer\GAL4^A9, dpp^UAS.cUa has wing phenotype, suppressible | partially by Scer\GAL4^A9/sog^UAS.cYa/tsg^UAS.cYa

(Ross et al., 2001)

Scer\GAL4^A9, dpp^UAS.cUa, sog^UAS.cYa has wing vein phenotype, suppressible by Scer\GAL4^A9/tsg^UAS.cYa

(Ross et al., 2001)

Scer\GAL4^A9, dpp^UAS.cUa, tsg^UAS.cYa has wing vein phenotype, suppressible by Scer\GAL4^A9/sog^UAS.cYa

(Ross et al., 2001)

Scer\GAL4^A9, dpp^UAS.cUa, sog^UAS.cYa has wing phenotype, suppressible by Scer\GAL4^A9/tsg^UAS.cYa

(Ross et al., 2001)

Scer\GAL4^A9, dpp^UAS.cUa, tsg^UAS.cYa has wing phenotype, suppressible by Scer\GAL4^A9/sog^UAS.cYa

(Ross et al., 2001)

Scer\GAL4^A9, dpp^UAS.cUa has wing vein | ectopic phenotype, suppressible by Xlae\nog.L^UAS.cYa/Scer\GAL4^A9

(Yu et al., 2000)

Scer\GAL4^A9, dpp^UAS.cUa has wing cell phenotype, suppressible by Xlae\nog.L^UAS.cYa/Scer\GAL4^A9

(Yu et al., 2000)

Scer\GAL4^A9, dpp^UAS.cUa has wing phenotype, suppressible | partially by Xlae\nog.L^UAS.cYa/Scer\GAL4^A9

(Yu et al., 2000)

Scer\GAL4^A9, dpp^UAS.cUa has wing vein | ectopic phenotype, suppressible by Scer\GAL4^A9/sog^{supersog1.UAS}

(Yu et al., 2000)

Scer\GAL4^A9, dpp^UAS.cUa has wing cell phenotype, suppressible by Scer\GAL4^A9/sog^{supersog1.UAS}

(Yu et al., 2000)

Scer\GAL4^A9, dpp^UAS.cUa has wing phenotype, suppressible | partially by Scer\GAL4^A9/sog^{supersog1.UAS}

(Yu et al., 2000)

Scer\GAL4^A9, dpp^UAS.cUa has wing phenotype, suppressible | partially by Scer\GAL4^A9/tkv^1ΔGSK.UAS

(Haerry et al., 1998, Nguyen et al., 1998)

Scer\GAL4^A9, dpp^UAS.cUa has wing phenotype, suppressible by dally^ΔP-527/dally[+]

(Jackson et al., 1997)

NOT suppressed by

Statement

Reference

Scer\GAL4^A9, dpp^UAS.cUa has wing phenotype, non-suppressible by Scer\GAL4^A9/sog^UAS.cYa/cv^UAS.cVa

(Vilmos et al., 2005)

Scer\GAL4^A9, dpp^UAS.cUa has wing phenotype, non-suppressible by Scer\GAL4^A9/cv^UAS.cVa

(Vilmos et al., 2005)

Scer\GAL4^A9, dpp^UAS.cUa has wing vein phenotype, non-suppressible by Scer\GAL4^A9/tsg^UAS.cYa

(Ross et al., 2001)

Scer\GAL4^A9, dpp^UAS.cUa has wing phenotype, non-suppressible by Scer\GAL4^A9/sog^UAS.cYa

(Ross et al., 2001, Nguyen et al., 1998)

Scer\GAL4^A9, dpp^UAS.cUa has wing phenotype, non-suppressible by Scer\GAL4^A9/tsg^UAS.cYa

(Ross et al., 2001)

Scer\GAL4^A9, dpp^UAS.cUa has wing vein phenotype, non-suppressible by Scer\GAL4^A9/sog^UAS.cYa

(Ross et al., 2001, Yu et al., 2000)

Scer\GAL4^A9, dpp^UAS.cUa has wing phenotype, non-suppressible by Scer\GAL4^A9/sax^ΔI.UAS

(Haerry et al., 1998, Nguyen et al., 1998)

Suppressor of

Statement

Reference

dpp^UAS.cUa/Scer\GAL4^esg.PU is a suppressor of adult posterior midgut epithelium phenotype of Scer\GAL4^esg.PU, sfl^HMS00543

(Ma et al., 2019)

Scer\GAL4^nanos.PG/dpp^UAS.cUa is a suppressor | partially of spermatogonium | heat sensitive phenotype of Stat92E^F/Stat92E^j6C8

(Singh et al., 2006)

Scer\GAL4^nanos.PG/dpp^UAS.cUa is a suppressor | partially of male germline stem cell | heat sensitive phenotype of Stat92E^F/Stat92E^j6C8

(Singh et al., 2006)

Scer\GAL4^LE/dpp^UAS.cUa is a suppressor of embryonic epidermis | dorsal phenotype of arm³

(McEwen et al., 2000)

Scer\GAL4^ptc-559.1/dpp^UAS.cUa is a suppressor | partially of wing vein phenotype of Scer\GAL4^ptc-559.1, gbb^UAS.cKa

(Khalsa et al., 1998)

Scer\GAL4^ptc-559.1/dpp^UAS.cUa is a suppressor | partially of wing phenotype of Scer\GAL4^ptc-559.1, gbb^UAS.cKa

(Khalsa et al., 1998)

Scer\GAL4^71B/dpp^UAS.cUa is a suppressor | partially of wing vein phenotype of Scer\GAL4^71B, gbb^UAS.cKa

(Khalsa et al., 1998)

Scer\GAL4^71B/dpp^UAS.cUa is a suppressor | partially of wing phenotype of Scer\GAL4^71B, gbb^UAS.cKa

(Khalsa et al., 1998)

Scer\GAL4^A9/dpp^UAS.cUa is a suppressor | partially of wing vein phenotype of Scer\GAL4^A9, gbb^UAS.cKa

(Khalsa et al., 1998)

Scer\GAL4^A9/dpp^UAS.cUa is a suppressor | partially of wing phenotype of Scer\GAL4^A9, gbb^UAS.cKa

(Khalsa et al., 1998)

NOT Suppressor of

Statement

Reference

Scer\GAL4^A9/dpp^UAS.cUa is a non-suppressor of wing phenotype of Scer\GAL4^A9, cv^UAS.cVa, sog^UAS.cYa

(Vilmos et al., 2005)

Other

Statement

Reference

Scer\GAL4^A9, dpp^UAS.cUa, sog^UAS.cYa has wing phenotype

(Ross et al., 2001)

Scer\GAL4^A9, dpp^UAS.cUa, sog^UAS.cYa has wing vein phenotype

(Ross et al., 2001)

Scer\GAL4^A9, dpp^UAS.cUa, tsg^UAS.cYa has wing phenotype

(Ross et al., 2001)

Scer\GAL4^A9, dpp^UAS.cUa, tsg^UAS.cYa has wing vein phenotype

(Ross et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of cv-2^Scer\UAS.cSa suppresses the wing phenotypes seen when dpp^Scer\UAS.cHa is expressed under the control of Scer\GAL4^A9.

(Serpe et al., 2008)

A tkv⁷/+ background strongly suppresses the wing phenotype of Scer\GAL4^A9>dpp^Scer\UAS.cHa flies so that almost 50% of wings appear wild type.

A sax⁴/+ background causes a mild suppression of the Scer\GAL4^A9>dpp^Scer\UAS.cHa wing phenotype; with fewer wings showing the more severe forms of the phenotype.

(Bangi and Wharton, 2006)

Expression of dpp^Scer\UAS.cUa under the control of Scer\GAL4^nos.PG significantly slows down the loss of germ cell phenotype that is seen in Stat92E^F/Stat92E^j6C8 testes at 29[o]C. After 4 days at 29[o]C, 41% of the double mutant testes contain one or more germline stem cells and all of the testes retain spermatogonia. After 7 days at 29[o]C, 17% of the double mutant testes have one or more germline stem cells and 88% retain spermatogonia.

Co-expression of BHD^{dsRNA.Sym.Scer\UAS} significantly suppresses the male germline stem cell expansion phenotype caused by expression of dpp^Scer\UAS.cUa under the control of Scer\GAL4^nos.PG.

(Singh et al., 2006)

Co-expression of cv^Scer\UAS.cVa with dpp^Scer\UAS.cHa, under the regulation of Scer\GAL4^A9 has no detectable effect on the overexpression phenotype of dpp^Scer\UAS.cHa (wing disruption). Co-expression of cv^Scer\UAS.cVa and sog^Scer\UAS.cYa, with dpp^Scer\UAS.cHa, under the regulation of Scer\GAL4^A9 has no detectable effect on the overexpression phenotype of dpp^Scer\UAS.cHa (wing disruption).

(Vilmos et al., 2005)

Expression of sog^Scer\UAS.cYa and tsg^Scer\UAS.cYa, but not either alone, driven by Scer\GAL4^A9 rescues the wing shape and wing vein phenotype of dpp^Scer\UAS.cHa driven by Scer\GAL4^A9.

(Ross et al., 2001)

The solid vein phenotype caused by expression of dpp^Scer\UAS.cHa under the control of Scer\GAL4^A9 is not suppressed by co-expression of sog^Scer\UAS.cYa. Co-expression of sog^{supersog1.Scer\UAS} partially suppresses the broadened wing phenotype caused by expression of dpp^Scer\UAS.cHa under the control of Scer\GAL4^A9 and almost completely suppresses the conversion of intervein regions into veins.

(Yu et al., 2000)

The wing phenotype caused by expression of dpp^Scer\UAS.cHa under the control of Scer\GAL4^A9 is not suppressed if the flies are also coexpressing sax^ΔI.Scer\UAS, but is partially suppressed if the flies are also coexpressing tkv^{1ΔGSK.Scer\UAS}.

(Haerry et al., 1998)

Partially suppresses the wing defects caused by gbb^Scer\UAS.cKa when co-expressed under the control of Scer\GAL4^ptc-559.1, Scer\GAL4^71B or Scer\GAL4^A9.

(Khalsa et al., 1998)

Co-expression of one copy of sax^ΔI.Scer\UAS or four copies of sog^Scer\UAS.cYa has no effect on the wing phenotype caused by dpp^Scer\UAS.cHa expressed under the control of Scer\GAL4^A9. Co-expression of one copy of tkv^{1ΔGSK.Scer\UAS} partially suppresses the wing phenotype caused by dpp^Scer\UAS.cHa expressed under the control of Scer\GAL4^A9.

(Nguyen et al., 1998)

The wing margin defects produced when dpp^Scer\UAS.cHa is expressed using Scer\GAL4^A9 are suppressed if the flies are also heterozygous for dally^ΔP-527.

(Jackson et al., 1997)

Similar dominant wing phenotypes are observed in flies expressing dpp^Scer\UAS.cHa and tkv^{Q199D.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^unspecified that are not observed in flies expressing tkv^Scer\UAS.cHa under the control of Scer\GAL4^unspecified.

(Hoodless et al., 1996)

Xenogenetic Interactions

Statement

Reference

Co-expression of Xlae\noggin^Scer\UAS.cYa partially suppresses the broadened wing phenotype caused by expression of dpp^Scer\UAS.cHa under the control of Scer\GAL4^A9 and almost completely suppresses the conversion of intervein regions into veins.

(Yu et al., 2000)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

dpp^Scer\UAS.cHa

dpp^Scer\UAS.cUa

dpp^UAS.cHa

dpp^UAS.cUa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Hoodless

(Hoodless et al., 1996)

Saccharomyces cerevisiae UAS construct a of Unknown

Secondary FlyBase IDs

FBal0221546
FBal0051659

References (47)

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