FlyBase Allele Report: Dmel\dally[ΔP-527]

General Information

Symbol

Dmel\dally^ΔP-527

Species

D. melanogaster

Name

FlyBase ID

FBal0045496

Feature type

allele

Associated gene

Dmel\dally

Associated Insertion(s)

P{?'PZ}dally^ΔP-527

Carried in Construct

Also Known As

dally^δP527

Key Links

Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Tsuda et al., 1999)

loss of function allele

(Nakato et al., 1995)

Mutagen

Delta2-3 transposase

(Nakato et al., 1995)

Progenitor genotype

dally^P1

(Nakato et al., 1995)

Associated Insertion(s)

P{?'PZ}dally^ΔP-527

Cytology

Description

Imprecise excision that removes genomic sequences adjacent to the site of insertion.

(Nakato et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

segment polarity phenotype

(Tsuda et al., 1999)

visible

(Nakato et al., 1995)

Phenotype Manifest In

antenna

(Nakato et al., 1995)

anterior dorsocentral bristle (with dally^gem)

(Kirkpatrick et al., 2006, Fujise et al., 2001)

dorsocentral bristle | increased number (with dally^gem), with Scer\GAL4^A9, dally^UAS.cJa

(Kirkpatrick et al., 2006)

embryo

(Tsuda et al., 1999)

embryonic/first instar larval cuticle

(Tsuda et al., 1999)

embryonic epidermis

(Tsuda et al., 1999)

eye

(Nakato et al., 1995)

genitalia

(Nakato et al., 1995)

posterior dorsocentral bristle (with dally^gem)

(Fujise et al., 2001)

posterior postalar bristle (with dally^gem)

(Luders et al., 2003)

posterior supraalar bristle (with dally^gem)

(Kirkpatrick et al., 2006, Fujise et al., 2001)

sensory mother cell (with dally^gem)

(Fujise et al., 2001)

wing (with dally^gem)

(Luders et al., 2003)

wing margin bristle | anterior (with dally^gem)

(Kirkpatrick et al., 2006)

wing nerve TSM(1) & sensillum campaniformium (with dally^gem)

(Fujise et al., 2001)

wing nerve TSM(2) & sensillum campaniformium (with dally^gem)

(Fujise et al., 2001)

wing vein

(Nakato et al., 1995)

wing vein L5 (with dally^gem)

(Kirkpatrick et al., 2006, Luders et al., 2003)

Detailed Description

Statement

Reference

dally^gem/dally^ΔP-527 flies show a reduction in the number of chemosensory bristles at the anterior margin of the wing compared to wild-type flies. The L5 vein in the wings of these flies does not form properly and stops short between the posterior crossvein and the wing margin. These mutants also show a loss of the anterior dorsocentral bristles and the posterior supraalar bristles on the notum.

Expression of dally^Scer\UAS.cJa under the control of Scer\GAL4^A9 in a dally^gem/dally^ΔP-527 or dally^gem mutant background results in the formation of excess dorsocentral bristles (the excess is around 30% compared to wild-type wings).

(Kirkpatrick et al., 2006)

Homozygous embryos do not show muscles crossing the ventral midline at stages 13-15 or inner Fas2-positive axons crossing the midline at stages 16 and 17.

(Steigemann et al., 2004)

In dally^gem/dally^ΔP-527 adults, the posterior postalar bristle (pPA) is absent from 5% of all individuals. These adults also display defects in wing patterning. In addition to notches in the margin, the wings of these mutants show a truncation of longitudinal vein L5.

(Luders et al., 2003)

dally^ΔP-527/dally^gem animals show a loss of both twin campaniform sensilla of the margin (TSM1 and 2) in 70% of animals. In dally^gem/dally^ΔP-527 flies, 98% of animals lack the posterior supraalar bristle (pSA), 93% the anterior dorsocentral bristles (aDC) and 3% the posterior supraalar bristle (pSA). In the wing disc of dally^ΔP-527/dally^gem animals, the number of sensory organ mother cells (SMCs) for chemosensory bristles at the anterior wing margin is severely reduced, as compared to wild-type discs. An absence of the SMCs for the aDC, pSA are also observed in these wing discs. The size of the TSM proneural cluster is severely decreased in these mutants, whilst the L3 proneural cluster remains unaffected.

(Fujise et al., 2001)

dally^ΔP-527/dally⁰⁶⁴⁶⁴ mutant embryos show a loss of naked cuticle and abnormalities with segment polarity (21% penetrance).

(Tsuda et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

dally^ΔP-527/dally[+] is a non-enhancer of visible | dominant phenotype of sog^EP7

(Araujo et al., 2003)

dally^ΔP-527/dally[+] is a non-enhancer of visible | dominant phenotype of sog^EP11

(Araujo et al., 2003)

Suppressor of

Statement

Reference

dally^ΔP-527/dally[+] is a suppressor of visible phenotype of Scer\GAL4^A9, dpp^UAS.cUa

(Jackson et al., 1997)

NOT Suppressor of

Statement

Reference

dally^ΔP-527/dally[+] is a non-suppressor of visible | dominant phenotype of sog^EP11

(Araujo et al., 2003)

dally^ΔP-527/dally[+] is a non-suppressor of visible | dominant phenotype of sog^EP7

(Araujo et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

dally^ΔP-527/dally^gem has posterior postalar bristle phenotype, enhanceable by sll^7E18

(Luders et al., 2003)

NOT Enhancer of

Statement

Reference

dally^ΔP-527/dally[+] is a non-enhancer of wing vein phenotype of sog^EP7

(Araujo et al., 2003)

dally^ΔP-527/dally[+] is a non-enhancer of wing vein phenotype of sog^EP11

(Araujo et al., 2003)

Suppressor of

Statement

Reference

dally^ΔP-527/dally[+] is a suppressor of wing phenotype of Scer\GAL4^A9, dpp^UAS.cUa

(Jackson et al., 1997)

NOT Suppressor of

Statement

Reference

dally^ΔP-527/dally[+] is a non-suppressor of wing vein phenotype of sog^EP11

(Araujo et al., 2003)

dally^ΔP-527/dally[+] is a non-suppressor of wing vein phenotype of sog^EP7

(Araujo et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of sll^7E18 to dally^gem/dally^ΔP-527 animals enhances the posterior postalar bristle phenotype - 30% of individuals show this phenotype.

(Luders et al., 2003)

Dominantly suppresses the wing margin defects produced when dpp^Scer\UAS.cHa is expressed using Scer\GAL4^A9.

(Jackson et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

dally^ΔP-527/dally^gem is partially rescued by Scer\GAL4^A9/dally^{ΔGAG.UAS.Tag:MYC}

(Kirkpatrick et al., 2006)

dally^ΔP-527/dally^gem is partially rescued by Scer\GAL4^A9/dally^ΔGAG.UAS

(Kirkpatrick et al., 2006)

Comments

Expression of dally^{ΔGAG.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^A9 restores the L5 wing vein in 76% of dally^gem/dally^ΔP-527 transheterozygotes. It performs a slight rescue of the number of chemosensory bristles in dally^gem/dally^ΔP-527 flies but does not restore posterior supraalar bristles.

Expression of dally^{ΔGAG.Scer\UAS} under the control of Scer\GAL4^A9 partially rescues the phenotypes of dally^gem/dally^ΔP-527 mutants. The transgene substantially restores chemosensory bristle numbers in the wing margin, almost fully rescues the formation of wing vein L5, almost fully restores the formation of the anterior dorsocentral bristles on the notum without inducing the formation of extra ones for all mutants. However, it fails to restore formation of the posterior supraalar bristles.

(Kirkpatrick et al., 2006)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

dally⁵²⁷

(Luders et al., 2003)

dally^ΔP-527

(Dejima et al., 2011)

dally^δP527

(Kirkpatrick et al., 2006, Araujo et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (10)

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