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General Information
Symbol
Dmel\EcRQ50st
Species
D. melanogaster
Name
FlyBase ID
FBal0083488
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
EcRQ50
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C6123413T

Reported nucleotide change:

C?T

Amino acid change:

Q50term | EcR-PB; Q50term | EcR-PG

Reported amino acid change:

Q50term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Mutation is within the EcR-B1 specific exon 2.

Nucleotide substitution: C?T.

Amino acid replacement: Q50term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

One copy of EcRQ50st has no effect on hemocyte proliferation in third instar larvae.

Mutants that lack EcR-B1 (e.g. EcRQ50st/EcR31) exhibit no difference in Crz-expressing ventral nerve cord neuronal cell death compared to wild-type.

Some EcRQ50st/EcRM554fs animals survive to the third larval instar stage, but they do not pupariate. They initiate wandering, but fail to evert spiracles, shorten, attach themselves to a solid surface, or harden their cuticle. The larvae easily slip free of their cuticle when dissected, indicating that apolysis of the larval cuticle has been completed.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
NOT Suppressor of
Statement
Reference
Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The G9aScer\UAS.cKa wing vein phenotype is almost completely suppressed by a heterozygous EcRQ50st background.

Df(2L)let-7-CKO1/EcRQ50st ; P{W8,let-7-CΔlet-7} animals have defects in the mushroom body α/β lobes: the lobes may appear slim or underdeveloped, axonal projections may be misguided.

usp4/+ ; EcRQ50st/+ animals have defects in the mushroom body α/β lobes: the lobes may appear slim or the β lobes may be fused.

EcRQ50st/tai61G1 germaria have additional germline stem cells and enlarged niches compared to wild type.

One copy of EcRQ50st is unable to suppress the hemocyte overproliferation seen in hopTum mutant third instar larvae.

Xenogenetic Interactions
Statement
Reference

One copy of EcRQ50st strongly suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1Scer\UAS.cSa is expressed under the control of Scer\GAL4Hml.Δ.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (12)