FlyBase Allele Report: Dmel\tai[61G1]

General Information

Symbol

Dmel\tai^61G1

Species

D. melanogaster

Name

FlyBase ID

FBal0120317

Feature type

allele

Associated gene

Dmel\tai

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(McDonald et al., 2003)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage | somatic clone

(Zhang et al., 2015)

Phenotype Manifest In

adult head | somatic clone

(Zhang et al., 2015)

border follicle cell

(Jang et al., 2009)

border follicle cell (with tai⁰¹³⁵¹)

(Bai et al., 2000)

border follicle cell (with tai^k05809)

(McDonald et al., 2003)

border follicle cell | somatic clone

(Bai et al., 2000)

eye | somatic clone

(Zhang et al., 2015)

female germline stem cell | increased number (with tai⁰¹³⁵¹)

(König et al., 2011)

female germline stem cell | increased number (with tai^BG02711)

(König et al., 2011)

female germline stem cell | increased number (with tai^EY11718)

(König et al., 2011)

female germline stem cell | increased number (with tai^k15101)

(König et al., 2011)

female germline stem cell | increased number (with tai^KG02309)

(König et al., 2011)

germarium cap cell | increased number (with tai⁰¹³⁵¹)

(König et al., 2011)

germarium cap cell | increased number (with tai^BG02711)

(König et al., 2011)

germarium cap cell | increased number (with tai^k15101)

(König et al., 2011)

germarium cap cell | increased number (with tai^KG02309)

(König et al., 2011)

germarium cap cell | somatic clone

(König et al., 2011)

wing | somatic clone

(Zhang et al., 2015)

Detailed Description

Statement

Reference

tai^61G1/tai^61G1 mosaic adult wings are reduced in size relative to controls, and tai^61G1/tai^61G1 mosaic adult heads exhibit smaller head and eye size as compared to controls.

(Zhang et al., 2015)

The number of niche cap cells and the number of germline stem cells per germarium is increased compared to wild type females transheterozygous for tai^61G1 and either tai^BG02711, tai^k15101, tai⁰¹³⁵¹ or tai^KG02309.

The number of germline stem cells per germarium is increased compared to wild type in tai^61G1/tai^EY11718 females.

Homozygous clones induced in the somatic niche cap cells during niche formation result in germaria with substantially enlarged niches.

(König et al., 2011)

Homozygous border cell clones show a fully penetrant border-cell migration defect.

(Jang et al., 2009)

Heterozygous egg chambers are indistinguishable from wild type. Border follicle cells show migration defects in stage 10 tai^61G1/tai^k05809 egg chambers; in 74% of egg chambers they have migrated 76-100% the normal distance, in 15% they have migrated 51-75% the normal distance, in 6% they have migrated 26-50% the normal distance and in 5% they have migrated 0-25% the normal distance.

(McDonald et al., 2003)

In some egg chambers containing homozygous clones, border cell migration is completely inhibited, and the border cells remain at the anterior tip of the egg chamber at stage 10. In other egg chambers, the border cells undergo partial migration. Border cell clusters that undergo partial migration are typically composed of a mixture of heterozygous and homozygous cells. tai⁰¹³⁵¹/tai^61G1 escapers show border cell migration defects and reduced fertility.

(Bai et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

tai[+]/tai^61G1 is a suppressor of abnormal size phenotype of Scer\GAL4^en.PU, crb^{intra.UAS.Tag:MYC}

(Zhang et al., 2015)

tai^61G1/tai^61G1 is a suppressor of abnormal size | somatic clone | adult stage phenotype of ex^e1

(Zhang et al., 2015)

Other

Statement

Reference

Scer\GAL4^GMR.PU, tai^61G1, yki^{S168A.UAS.YFP} has abnormal size | adult stage phenotype

(Zhang et al., 2015)

Phenotype Manifest In

Enhancer of

Statement

Reference

tai^k05809/tai^61G1 is an enhancer of border follicle cell phenotype of Pvf1^UAS.cMa, Scer\GAL4^slbo.2.6

(McDonald et al., 2003)

tai[+]/tai^61G1 is an enhancer of border follicle cell phenotype of Pvf1^UAS.cMa, Scer\GAL4^slbo.2.6

(McDonald et al., 2003)

Suppressor of

Statement

Reference

tai[+]/tai^61G1 is a suppressor of wing phenotype of Scer\GAL4^en.PU, crb^{intra.UAS.Tag:MYC}

(Zhang et al., 2015)

tai^61G1/tai^61G1 is a suppressor of wing | somatic clone phenotype of ex^e1

(Zhang et al., 2015)

tai^61G1/tai^61G1 is a suppressor of adult head | somatic clone phenotype of ex^e1

(Zhang et al., 2015)

tai^61G1/tai^61G1 is a suppressor of eye | somatic clone phenotype of ex^e1

(Zhang et al., 2015)

tai^61G1/tai^61G1 is a suppressor of eye phenotype of Scer\GAL4^GMR.PU, yki^{S168A.UAS.YFP}

(Zhang et al., 2015)

Other

Statement

Reference

Scer\GAL4^GMR.PU, tai^61G1, yki^{S168A.UAS.YFP} has adult head phenotype

(Zhang et al., 2015)

ex^e1, tai^61G1 has wing disc | third instar larval stage phenotype

(Zhang et al., 2015)

EcR^Q50st, tai^61G1 has female germline stem cell | increased number phenotype

(König et al., 2011)

EcR^Q50st, tai^61G1 has germarium cap cell | increased number phenotype

(König et al., 2011)

Df(3L)AC1/+, tai^61G1 has border follicle cell phenotype

(McDonald et al., 2003)

Df(3L)GN24/+, tai^61G1 has border follicle cell phenotype

(McDonald et al., 2003)

Df(3L)fz-GF3b/+, tai^61G1 has border follicle cell phenotype

(McDonald et al., 2003)

Df(3R)3-4/+, tai^61G1 has border follicle cell phenotype

(McDonald et al., 2003)

Df(3R)3450/+, tai^61G1 has border follicle cell phenotype

(McDonald et al., 2003)

Df(3R)H-B79/+, tai^61G1 has border follicle cell phenotype

(McDonald et al., 2003)

Df(3R)by10/+, tai^61G1 has border follicle cell phenotype

(McDonald et al., 2003)

Df(3R)by62/+, tai^61G1 has border follicle cell phenotype

(McDonald et al., 2003)

Df(3R)crb-F89-4/+, tai^61G1 has border follicle cell phenotype

(McDonald et al., 2003)

Df(3R)crb87-4/+, tai^61G1 has border follicle cell phenotype

(McDonald et al., 2003)

Pvf1^EP1624, tai[+]/tai^61G1 has border follicle cell phenotype

(McDonald et al., 2003)

Tp(3;Y)ry506-85C/+, tai^61G1 has border follicle cell phenotype

(McDonald et al., 2003)

Pvf1^EP1624, tai^61G1 has border follicle cell phenotype

(McDonald et al., 2003)

Df(1)v-N48/+, tai^61G1 has border follicle cell phenotype

(McDonald et al., 2003)

Df(1)N19/+, tai^61G1 has border follicle cell phenotype

(McDonald et al., 2003)

+/Df(2L)BSC7, tai^61G1 has border follicle cell phenotype

(McDonald et al., 2003)

Df(2L)Dwee-δ5/+, tai^61G1 has border follicle cell phenotype

(McDonald et al., 2003)

Df(2L)J2/+, tai^61G1 has border follicle cell phenotype

(McDonald et al., 2003)

Df(2L)J39/+, tai^61G1 has border follicle cell phenotype

(McDonald et al., 2003)

Df(2R)M60E/+, tai^61G1 has border follicle cell phenotype

(McDonald et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

tai^61G1/tai^61G1, ex^e1/ex^e1 mosaic adult wings are smaller than ex^e1/ex^e1 mosaic wings, although the wings are still a broader shape than controls; tai^61G1/tai^61G1, ex^e1/ex^e1 clones in the L3 wing disc appear smaller than age-matched ex^e1/ex^e1 clones; tai^61G1/tai^61G1, ex^e1/ex^e1 mosaic heads have suppressed head and eye overgrowth as compared to ex^e1/ex^e1 clones.

tai^61G1/tai^61G1 clones lead to reduced head and eye size in flies expressing yki^{S168A.Scer\UAS.T:Avic\GFP-YFP} under the control of Scer\GAL4^GMR.PU.

The presence of tai^61G1/+ suppresses the enlarged wings of adult females expressing crb^{intra.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^en.PU.

(Zhang et al., 2015)

About 6% of Pvf1^EP1624 tai^61G1 double heterozygous egg chambers have border cell migration defects. The border cells migration defects caused by expression of Pvf1^Scer\UAS.cMa under the control of Scer\GAL4^slbo.2.6 are enhanced by tai^61G1/+; 90% of double mutant stage 10 egg chambers show border cell migration defects. The border cells migration defects caused by expression of Pvf1^Scer\UAS.cMa under the control of Scer\GAL4^slbo.2.6 are enhanced by tai^61G1/tai^k05809; all the double mutant egg chambers show border cell migration defects.

(McDonald et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

tai⁰¹³⁵¹

(Bai et al., 2000)

Rescued by

tai^61G1 is rescued by Scer\GAL4^c306/tai^UAS.cBa

(Jang et al., 2009)

tai^61G1 is rescued by Scer\GAL4^c306/tai^UAS.cBa

(Bai et al., 2000)

Partially rescued by

tai^61G1 is partially rescued by Scer\GAL4^c306/tai^ΔB.UAS

(Jang et al., 2009)

Not rescued by

tai^61G1 is not rescued by tai^{LXXLL.UAS.GFP,Tag:NLS(Unk)}/Scer\GAL4^c306

(Jang et al., 2009)

tai^61G1 is not rescued by Scer\GAL4^c306/tai^{bHLH.UAS.Tag:FLAG,Tag:NLS(Unk)}

(Jang et al., 2009)

tai^61G1 is not rescued by Scer\GAL4^c306/tai^{PAS.UAS.Tag:FLAG,Tag:NLS(Unk)}

(Jang et al., 2009)

tai^61G1 is not rescued by tai^{BP.UAS.Tag:FLAG,Tag:NLS(Unk)}/Scer\GAL4^c306

(Jang et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

6379

dpy^ov1 tai^61G1 P{neoFRT}40A/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

tai^61G1

(Alyagor et al., 2018, Manning et al., 2017, Zhang et al., 2015, Geisbrecht et al., 2013, König et al., 2011, Cobreros-Reguera et al., 2010, Jang et al., 2009)

tai^G161

(König et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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