FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\GluRIIBMhc.Tag:MYC
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General Information
Symbol
Dmel\GluRIIBMhc.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0085980
Feature type
allele
Associated gene
Dmel\GluRIIB
Associated Insertion(s)
Carried in Construct
P{Mhc.GluRIIB.Myc}
Also Known As
MHC-GluRIIB-Myc
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Davis et al., 1998, Petersen et al., 1997)
Progenitor genotype
Carried in construct
P{Mhc.GluRIIB.Myc}
Cytology
Description

A Tag:MYC epitope has been incorporated immediately following a heterologous signal sequence used to replace the endogenous signal sequence. This epitope is present at the extracellular N-terminus of the receptor coding region. Expression is driven by Mhc promoter sequences.

(Petersen et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
Mhc
Encoded product / tool
GluRIIB
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter or direct label
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      muscle cell of ventral cervical muscle 26
      (Rivlin et al., 2004)
      muscle cell of prothoracic sternal adductor muscle 33
      (Rivlin et al., 2004)
      adult somatic muscle cell of abdomen
      (Rivlin et al., 2004)
      day 3 of adulthood
      muscle cell of ventral cervical muscle 25
      (Rivlin et al., 2004)
      Additional Information
      Statement
      Reference

      In the adult prothorax and neck, Myc-tagged GluRIIB protein is observed at the type I boutons of motor neurons innervating ventral cervical muscle 25 and prothoracic sternal adductor muscle 33 from the first day of adulthood, and ventral cervical muscle 26 from the third day of adulthood. GluRIIB protein is also observed at the type I boutons of all adult abdominal muscles. GluRIIB protein is not detected in Type II boutons.

      (Rivlin et al., 2004)
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of GluRIIBMhc.T:Hsap\MYC results in a decrease in the amplitude of miniature excitatory junctional potentials (mEJPs) at the larval neuromuscular junction.

      (Zelhof et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Glu-RIIBMhc.T:Hsap\MYC
      Glu-RIIBMhc.T:Myc
      GluRIIBMhc.T:Hsap\MYC
      GluRIIBMhc.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (11)