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General Information
Symbol
Dmel\ptcEP941
Species
D. melanogaster
Name
FlyBase ID
FBal0088689
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
EP(2)0941
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{EP} insertion 768bp upstream of the ptc translation initiation codon. The P{EP} element is oriented such that expression from the element should result in overexpression of ptc.

Insertion components
P{EP}ptcEP941
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of ptcEP941 under the control of Scer\GAL4Bx-MS1096 results in a reduction in the size of the AP axis of the wing and abolishes the L3/4 territory and much of wing vein L3.

Expression of ptcEP941 under the control of Scer\GAL4bi-omb-Gal4 produces wings of reduced size, particularly in the region between veins 3 and 4.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

ptcEP941/Scer\GAL4h-H10 is a suppressor of visible phenotype of roDOM

Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Wings of flies co-expressing ptcEP941 and high levels of smoScer\UAS.cHa.T:Hsap\MYC under the control of Scer\GAL4Bx-MS1096 are indistinguishable from those of flies expressing ptcEP941 alone. Co-expression of ptcEP941 has no effect on the anterior overgrowth of the wing or ectopic venation caused by expression of high levels of fz::smoFFS.Scer\UAS under the control of Scer\GAL4Bx-MS1096, although ectopic venation is seen in a broad zone around the wing in these flies. Co-expression of ptcEP941 completely suppresses the ectopic venation and costal overgrowth caused by expression of smoC.Scer\UAS.T:Hsap\MYC,T:Uuuu\Myr4 under the control of hemizygous Scer\GAL4Bx-MS1096 and instead reduces the wing to a tiny scrap.

pnrMD237/+ adults expressing ptcEP941 under the control of Scer\GAL4pnr-MD237 do not form a scutellum.

When expression is driven by Scer\GAL4h-H10 in a roDOM mutant the stop-furrow phenotype of roDOM is substantially suppressed.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: a P{EP} insertion line that modifies the pnrMD237/+ phenotype when expressed using Scer\GAL4pnr-MD237.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
EP(2)0941ptc
ptcEP941
ptc[Ep941]
Name Synonyms
Secondary FlyBase IDs
    References (7)