FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\hthP1-K1-8
Open Close
General Information
Symbol
Dmel\hthP1-K1-8
Species
D. melanogaster
Name
FlyBase ID
FBal0089226
Feature type
allele
Associated gene
Dmel\hth
Associated Insertion(s)
P{lacW}hthP1-K1-8
Carried in Construct
Also Known As
hthK1-8
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Henderson and Andrew, 2000, Kurant et al., 1998)
Mutagen
P-element activity
(Kurant et al., 1998, Pai et al., 1998)
Progenitor genotype
hthMeis1-P1
(Kurant et al., 2001, Kurant et al., 1998, Pai et al., 1998)
Associated Insertion(s)
P{lacW}hthP1-K1-8
Caused by aberration
Df(3R)P1-K1-8
Cytology
Description

Imprecise excision of the P{lacW} element, and local hop of the P{lacW} element resulting in the insertion P{lacW}hthP1-K1-8. The insertion maps to intron 11, approximately 1900bp downstream of exon 11 and 4700bp upstream of exon 12 in hthP1-K1-8.

(Kurant et al., 2001)

Imprecise excision of the P{lacW} element.

(Kurant et al., 1998)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      hthP1-K1-8 mutant embryos show similar axonal defects in the embryonic brain as exd1 embryos which lack both maternal and zygotic exd function, although the defects are slightly milder than those seen in the exd1 mutants.

      (Nagao et al., 2000)

      The LCh5 neurons are located in a more dorsal position than normal and have abnormal orientation in some abdominal segments in homozygous embryos. In addition, the number of LCh5 neurons is reduced, with nearly all abdominal segments containing only 3 dorsal chordotonal neurons.

      (Kurant et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      hthP5-GAL4

      (Tang and Sun, 2002)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      P-1K1-8
      (Kurant et al., 1998)
      P1-K1-8
      (Pai et al., 1998)
      hthK1-8
      (Zohar-Stoopel et al., 2014, Kurant et al., 2001, Henderson and Andrew, 2000, Nagao et al., 2000, Kurant et al., 1998)
      hthP1-K1-8
      Name Synonyms
      Secondary FlyBase IDs
        References (7)