FB2026_02 , released June 18, 2026
Allele: Dmel\Wnt2L
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General Information
Symbol
Dmel\Wnt2L
Species
D. melanogaster
Name
FlyBase ID
FBal0089484
Feature type
allele
Associated gene
Dmel\Wnt2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Kozopas et al., 1998)
Mutagen
ethyl methanesulfonate
(Kozopas et al., 1998)
Progenitor genotype
Cytology
Description

Amino acid replacement: C281Y.

(Kozopas et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:9,502,822..9,502,822 [+]
Nucleotide change:

G9502822A

Amino acid change:

C281Y | Wnt2-PA; C254Y | Wnt2-PB

Reported amino acid change:

C281Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Kozopas et al., 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Wnt2L/Wnt2O transheterozygous mutant males exhibit missing or incompletely developed testes. This phenotype is variable, with approximately 10% of the transheterozygous males being fertile.

      (Linnemannstöns et al., 2014)

      Mutant embryos do not show salivary gland defects.

      (Harris and Beckendorf, 2007)

      With variable penetrance, homozygous males have much smaller testes than wild-type. The hub cells, cyst cells and terminal epithelial cells are present. The germ cell lineage is also present. The outermost pigment layer, which normally covers both the testis and seminal vesicles, is absent. The muscle cell layer of the testis sheath is malformed or incomplete. Testis colour: the testis sheath lacks yellow pigmentation. Homozygotes have held out wings.

      (Kozopas et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      Wnt4C1/Wnt2L is a non-enhancer of lateral transverse muscle cell | embryonic stage 16 phenotype of Wnt5400

      (Lahaye et al., 2012)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      No lateral transverse muscle defects are observed in Wnt2L Wnt4C1 double mutant stage 16 embryos.

      Wnt2L and Wnt4C1 do not enhance the lateral transverse muscle attachment defects seen in Wnt5400 mutant stage 16 embryos.

      (Lahaye et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Generated in the same screen as Wnt2K, and has the same amino acid replacement, therefore the 2 mutations may not be independent events.

      (Kozopas et al., 1998)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (7)