FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Wnt2I
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General Information
Symbol
Dmel\Wnt2I
Species
D. melanogaster
Name
FlyBase ID
FBal0089486
Feature type
allele
Associated gene
Dmel\Wnt2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

heat sensitive loss of function allele

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Kozopas et al., 1998)

heat sensitive loss of function allele

(Kozopas, 2003.3)
Mutagen
ethyl methanesulfonate
(Kozopas et al., 1998)
Progenitor genotype
Cytology
Description

Amino acid replacement: G57D.

(Kozopas et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:9,501,484..9,501,484 [+]
Nucleotide change:

G9501484A

Amino acid change:

G57D | Wnt2-PA; G30D | Wnt2-PB

Reported amino acid change:

G57D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Kozopas et al., 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Huntington's disease
      modeled by Hsap\HTTQ93.ex1.UAS
      (Dupont et al., 2012)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      At 18oC: testes are wild type, ings show held-out phenotype, DFMs not studied in detail. At 29oC: testis phenotype: severe loss of pigment cells and muscle, indistinguishable from null phenotype. Held out wing phenotype: wings are held out, DFMs not studied in detail.

      (Kozopas, 2003.3)

      With variable penetrance, homozygous males have much smaller testes than wild-type. The hub cells, cyst cells and terminal epithelial cells are present. The germ cell lineage is also present. The outermost pigment layer, which normally covers both the testis and seminal vesicles, is absent. The muscle cell layer of the testis sheath is malformed or incomplete. Testis colour: the testis sheath lacks yellow pigmentation. Homozygotes have held out wings.

      (Kozopas et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Wnt2[+]/Wnt2I is a suppressor | partially of short lived phenotype of Hsap\HTTQ93.ex1.UAS, Scer\GAL4elav.PU

      (Dupont et al., 2012)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Wnt2I/+ significantly partially suppresses the decreased lifespan seen in flies with expression of Hsap\HTTQ93.ex1p.Scer\UAS driven by Scer\GAL4elav.PU.

      (Dupont et al., 2012)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      DWnt2EMSI
      (Llimargas and Lawrence, 2001)
      Dwnt2I
      (Dupont et al., 2012)
      Wnt2I
      (Linnemannstöns et al., 2014, Christensen et al., 2008.4.15)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)