FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Met+tSt-H.hs
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General Information
Symbol
Dmel\Met+tSt-H.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0089549
Feature type
allele
Associated gene
Dmel\Met
Associated Insertion(s)
Carried in Construct
P{hs-Met.St-H}
Also Known As
p[w+EN71], EN71
Key Links
Genomic Maps

Transgenic product class
wild_type
(Ashok et al., 1998)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Ashok et al., 1998)
Mutagen
in vitro construct
(Ashok et al., 1998)
Progenitor genotype
Carried in construct
P{hs-Met.St-H}
Cytology
Description

StuI-HapI fragment encoding the Met open reading frame. Expression is influenced by an Hsp70 promoter and SV40 3' sequences.

(Ashok et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
Met
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
X:11,615,362..11,621,586 [+]
Linked to:
StuI-HpaI restriction fragment
Comment:

Position of restriction fragment on reference sequence inferred by FlyBase curator. Expression is influenced by an Hsp70 promoter and SV40 3' sequences.

(Ashok et al., 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The transgenic line expressing Met+tSt-H.hs shows higher susceptibility to methoprene than wild-type controls. The increased susceptibility is reflected by the survival values and by the increased fraction of adults from cultures exposed to lower sub-lethal dose that show methoprene-induced morphogenetic defects, such as sternite bristle defects or abnormally rotated male genitalia.

      (Barry et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Met+tSt-H.hs rescues Met3

      (Ashok et al., 1998)
      Comments

      The defective eye phenotype seen in Met27 flies is rescued by Met+tSt-H.hs.

      (Wilson et al., 2006)

      Rescues the ovipositional defects of Rst(1)JH27 homozygous females.

      (Wilson and Ashok, 1998)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Met+tSt-H.hs
      Rst(1)JH+tSt-H.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (6)