FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\IKKε3
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General Information
Symbol
Dmel\IKKε3
Species
D. melanogaster
Name
FlyBase ID
FBal0091356
Feature type
allele
Associated gene
Dmel\IKKε
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Kozlova et al., 1998)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G?A.

(Kuranaga et al., 2006)

This mutation is within the putative kinase domain of the expressed protein.

(Kuranaga et al., 2006)

Amino acid replacement: G19R.

(Kuranaga et al., 2006, Oshima et al., 2006)

Amino acid replacement: G19D.

(Shapiro and Anderson, 2006)

The amino acid replacement, caused by a point mutation, is found in the kinase domain of ik2.

(Shapiro and Anderson, 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:20,676,359..20,676,359 [+]
Nucleotide change:

G20676359A

Amino acid change:

G19R | IKKepsilon-PB; G19R | IKKepsilon-PC

Reported amino acid change:

G19D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Oshima et al., 2006, Shapiro and Anderson, 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Apoptosis occurs normally in l(2)38Ea46 and l(2)38Ea46/l(2)38Ea66 embryos.

      (Kuranaga et al., 2006)

      At low temperature and in uncrowded culture conditions, rare escaper ik23 adults (<1%) are observed, but they die shortly after eclosion. These escapers often exhibit abnormal bristles, both the interommatidial and the humeral bristles are affected. At high magnification, the actin footprints along the length of the bristle shaft in ik23 escaper adult eyes appears less organised than those in wild-type bristles. In wild-type, interommatidial bristles are found at alternating vertices, whereas in ik23 mutants these bristles are often duplicated at a single vertex and are misshapen and kinked.

      (Shapiro and Anderson, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      IKKε3 is a suppressor of eye phenotype of rprGMR.PH

      (Kuranaga et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      l(2)38Ea46 suppresses the eye ablation phenotype of flies that express rprGMR.PH.

      (Kuranaga et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      Reported As
      Symbol Synonym
      46
      (Oshima et al., 2006)
      APTX746
      (Kuranaga et al., 2006)
      DmIKKεG19R
      (Kuranaga et al., 2006)
      Ea46
      (Shapiro and Anderson, 2006)
      IKKε3
      ik23
      (Shapiro and Anderson, 2006)
      l(2)38Ea46
      (Kuranaga et al., 2006, Oshima, 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)