FlyBase Allele Report: Dmel\slmb[e4-1]

General Information

Symbol

Dmel\slmb^e4-1

Species

D. melanogaster

Name

FlyBase ID

FBal0092522

Feature type

allele

Associated gene

Dmel\slmb

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Deletes approximately 3kb including the slmb promoter and 5' transcript region.

(Theodosiou et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Theodosiou et al., 1998)

some die during embryonic stage | recessive

(Theodosiou et al., 1998)

Phenotype Manifest In

leg

(Theodosiou et al., 1998)

leg disc

(Theodosiou et al., 1998)

wing

(Theodosiou et al., 1998)

wing disc

(Theodosiou et al., 1998)

Detailed Description

Statement

Reference

Clones of mutant cells in the leg and wing discs cause outgrowths of slmb⁺ cells and pattern disruptions including duplicated structures. Outgrowths occur both ventrally and dorsally and both anteriorly and posteriorly.

(Theodosiou et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Mmus\Cul1^UAS.cHa, Scer\GAL4^Bx-MS1096, slmb^e4-1 has wing phenotype, suppressible by E2f1⁰⁷¹⁷²

(Heriche et al., 2003)

slmb^e4-1 has phenotype, suppressible by smo^D16

(Theodosiou et al., 1998)

NOT suppressed by

Statement

Reference

slmb^e4-1 has phenotype, non-suppressible by hh^rJ413

(Theodosiou et al., 1998)

Enhancer of

Statement

Reference

slmb^e4-1 is an enhancer of wing phenotype of Mmus\Cul1^UAS.cHa, Scer\GAL4^Bx-MS1096

(Heriche et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

A slmb^e4-1 background enhances the small wing phenotype found in Mmus\Cul1^Scer\UAS.cHa/Scer\GAL4^Bx-MS1096 over-expression mutants. The presence of E2f1⁰⁷¹⁷² as well as slmb^e4-1 reverses the enhancement of Mmus\Cul1^Scer\UAS.cHa/Scer\GAL4^Bx-MS1096 by a slmb^e4-1 background.

(Heriche et al., 2003)

Complementation and Rescue Data

Rescued by

slmb^e4-1 is rescued by slmb^hs.PT

(Theodosiou et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

shiva^e4-1

(Theodosiou et al., 1998)

slmb^e4-1

(Heriche et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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