FlyBase Allele Report: Dmel\sima[UAS.cBa]

General Information

Symbol

Dmel\sima^UAS.cBa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Bacon

FlyBase ID

FBal0092524

Feature type

allele

Associated gene

Dmel\sima

Associated Insertion(s)

Carried in Construct

P{UAS-sima.B}

Also Known As

UAS-sima

Key Links

Transgenic product class

wild_type

(Bacon et al., 1998)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Bacon et al., 1998)

Mutagen

in vitro construct

(Bacon et al., 1998)

Progenitor genotype

Carried in construct

P{UAS-sima.B}

Cytology

Description

UAS sequences drive sima expression.

(Bacon et al., 1998)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

sima

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease 7

modeled by dj-1β^ex54

(Lee et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of sima^UAS.cBa under the combined control of Scer\GAL4^pnr-MD237 and Gal80[ts], induced from pupal stage onward, results in viable adults displaying varying levels of thoracic pigmentation.

(Zhang et al., 2021)

Expression of sima^Scer\UAS.cBa under the control of Scer\GAL4^Toll-6-D42 leads to a significant decrease in climbing ability of adult flies.

(Cagin et al., 2015)

Expression of sima^Scer\UAS.cBa under the control of Scer\GAL4^tey-5053A results in an increase in the number of tracheal branches that terminate on ventrolateral body wall muscle 12 compared to controls.

(Mortimer and Moberg, 2013)

Ectopic expression of sima^Scer\UAS.cBa under the control of Scer\GAL4^slbo.2.6 results in the fully penetrant phenotype of a complete block of border cell migration. The clusters remain located at their place of original delamination from the follicle epithelium.

In the presence of Scer\GAL4^Scer\UAS.cHa, some of the border cells are able to migrate when sima^Scer\UAS.cBa in expressed ectopically under the control of Scer\GAL4^slbo.2.6. 11% of egg chambers show normal migration and 89% capable of some migration.

When sima^Scer\UAS.cBa is overexpressed using Scer\GAL4^c522, border cell migration is disrupted in all egg chambers. Although 87% of the clusters show a noticeable delay in migration, 13% of border cell clusters fail to migrate.

(Doronkin et al., 2010)

Expression of sima^Scer\UAS.cBa in clones under the expression of Scer\GAL4^Act5C.PP results in a marked autonomous reduction in cell size, which correlates with smaller nuclei.

(Centanin et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^Toll-6-D42, sima^UAS.cBa has abnormal locomotor behavior | adult stage phenotype, non-enhanceable by TFAM^UAS.cCa/Scer\GAL4^Toll-6-D42

(Cagin et al., 2015)

Suppressed by

Statement

Reference

Scer\GAL4^slbo.2.6, sima^UAS.cBa has abnormal cell migration phenotype, suppressible | partially by Hph⁰²²⁵⁵/Hph^f03923, Scer\GAL4^slbo.2.6

(Doronkin et al., 2010)

Scer\GAL4^slbo.2.6, sima^UAS.cBa has abnormal cell migration phenotype, suppressible | partially by Hph^f03923, Scer\GAL4^slbo.2.6

(Doronkin et al., 2010)

Scer\GAL4^slbo.2.6, sima^UAS.cBa has abnormal cell migration phenotype, suppressible | partially by Hph[+]/Hph^f03923, Scer\GAL4^slbo.2.6

(Doronkin et al., 2010)

NOT Enhancer of

Statement

Reference

sima^UAS.cBa/Scer\GAL4^Toll-6-D42 is a non-enhancer of abnormal locomotor behavior | adult stage phenotype of Scer\GAL4^Toll-6-D42, TFAM^UAS.cCa

(Cagin et al., 2015)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^slbo.2.6, sima^UAS.cBa has border follicle cell phenotype, suppressible | partially by Hph⁰²²⁵⁵/Hph^f03923, Scer\GAL4^slbo.2.6

(Doronkin et al., 2010)

Scer\GAL4^slbo.2.6, sima^UAS.cBa has border follicle cell phenotype, suppressible | partially by Hph^f03923, Scer\GAL4^slbo.2.6

(Doronkin et al., 2010)

Scer\GAL4^slbo.2.6, sima^UAS.cBa has border follicle cell phenotype, suppressible | partially by Hph[+]/Hph^f03923, Scer\GAL4^slbo.2.6

(Doronkin et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Any one of Hph^f03923/+, homozygous Hph^f03923 or trans-heterozygous Hph⁰²²⁵⁵/Hph^f03923 can partially suppresses the block in migration caused by Scer\GAL4^slbo.2.6>sima^Scer\UAS.cBa expression.

(Doronkin et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

9582

w^*; P{UAS-sima.B}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

sima^Scer\UAS.cBa

sima^UAS.cBa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Bacon

(Bacon et al., 1998)

Secondary FlyBase IDs

References (18)

Report Sections

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