FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\l(2)gd1d10
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General Information
Symbol
Dmel\l(2)gd1d10
Species
D. melanogaster
Name
FlyBase ID
FBal0092894
Feature type
allele
Associated gene
Dmel\l(2)gd1
Associated Insertion(s)
Carried in Construct
Also Known As
lgdd10
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    A 2 bp deletion at amino acid position 215 which results in a frame shift and a translational stop 14 amino acids downstream, leading to a truncated protein containing only the first DM14 domain.

    (Jaekel and Klein, 2006)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    deletion
    2L:11,107,795..11,107,796 [+]
    Comment:

    A two base pair deletion within amino acid 215 that results in a frameshift and translation termination 14aa downstream. The two deleted bases within the codon were not specified.

    (Jaekel and Klein, 2006)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        l(2)gd1d10 mutant clones induced in the head lack most external sensory organs, and the head is overgrown. Those that remain sometimes show a multi-socket phenotype. Mutant clones induced in the notum display a loss of hairs, and multi-sockets.

        (Gallagher and Knoblich, 2006)

        Homozygous larvae show overgrowth of the wing discs.

        (Santaren et al., 1998)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        l(2)gd11, l(2)gd14, l(2)gd1d7 and l(2)gd1d10 all harbor the same lesion.

        (Jaekel and Klein, 2006)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        l(2)gd1d10
        l(2)gdd10
        (Hernandez et al., 2004)
        lgdd10
        (Gallagher and Knoblich, 2006, Jaekel and Klein, 2006)
        Name Synonyms
        Secondary FlyBase IDs
          References (5)