FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\l(2)gd124
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General Information
Symbol
Dmel\l(2)gd124
Species
D. melanogaster
Name
FlyBase ID
FBal0246239
Feature type
allele
Associated gene
Dmel\l(2)gd1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Gallagher and Knoblich, 2006)
Mutagen
ethyl methanesulfonate
(Gallagher and Knoblich, 2006)
Progenitor genotype
Cytology
Description

Amino acid replacement: P557S.

(Gallagher and Knoblich, 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:11,108,878..11,108,878 [+]
Nucleotide change:

C11108878T

Amino acid change:

P557S | l(2)gd1-PA; P557S | l(2)gd1-PB

Reported amino acid change:

P557S

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Gallagher and Knoblich, 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      l(2)gd124 mutant flies show missing and abnormal external sensory organs, consisting of four sockets but no hair cells. Mutant heads are significantly enlarged.

      Postorbital bristles from l(2)gd124 mutant clones display multiple sockets but no hairs.

      (Gallagher and Knoblich, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      l(2)gd124 has visible phenotype, suppressible by HrsD28

      (Gallagher and Knoblich, 2006)
      Other
      Statement
      Reference

      Nl1N-ts1, l(2)gd124 has visible phenotype

      (Gallagher and Knoblich, 2006)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      l(2)gd124 has external sensory organ phenotype, suppressible by HrsD28

      (Gallagher and Knoblich, 2006)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The external sensory organ multi-socket phenotype in l(2)gd124 animals is suppressed in a HrsD28 mutant background.

      A postorbital bristle multiple socket phenotype is not observed when Nl1N-ts1 is inactivated in a l(2)gd124 mutant eye clones.

      (Gallagher and Knoblich, 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      2L24
      (Gallagher and Knoblich, 2006)
      l(2)gd124
      lgd24
      (Gallagher and Knoblich, 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)