FB2026_02 , released June 18, 2026
Allele: Dmel\eRF363D
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General Information
Symbol
Dmel\eRF363D
Species
D. melanogaster
Name
FlyBase ID
FBal0094034
Feature type
allele
Associated gene
Dmel\eRF3
Associated Insertion(s)
P{lacW}eRF363D
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Basu et al., 1998)
Mutagen
P-element activity
(Basu et al., 1998)
Progenitor genotype
Associated Insertion(s)
P{lacW}eRF363D
Cytology
Description

The P{lacW} is inserted 178 bp upstream of the putative Elf initiator ATG.

(Basu et al., 1998)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Spermatids have misshapen nuclei of variable volume, often in the form of extremely small micronuclei. Many spermatids have an abnormally large and misshapen Nebenkern associated with multiple nuclei. The mutation causes major irregularities in meiotic chromosome segregation and also disrupts cytokinesis. Spermatocytes show an array of problems in spindle assembly and behaviour: aster assembly and migration.

      (Basu et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Excision of the P{lacW} insertion reverts the mutant phenotype to wild type.

      (Basu et al., 1998)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Elf63D
      dsup3563D
      (Basu et al., 1998)
      eRF363D
      Name Synonyms
      Secondary FlyBase IDs
        References (1)