FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Hmgcrclb2
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General Information
Symbol
Dmel\Hmgcrclb2
Species
D. melanogaster
Name
FlyBase ID
FBal0094691
Feature type
allele
Associated gene
Dmel\Hmgcr
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Yi et al., 2006)
Progenitor genotype
Cytology
Description

Amino acid replacement: G566D. Nucleotide substitution: G2675A. Co-ordinates refer to the pNB36C cDNA.

(Van Doren and Lehmann, 2001.2.14)

A strong missense mutation.

(Van Doren et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:23,749,365..23,749,365 [+]
Nucleotide change:

G23749365A

Reported nucleotide change:

G2675A

Amino acid change:

G566D | Hmgcr-PA

Reported amino acid change:

G566D

(Van Doren and Lehmann, 2001.2.14, Goodman and Chang, 1985)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  neurodegenerative disease
      modeled by SNF4Aγloe
      (Tschäpe et al., 2002)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Primordial germ cell migration is disrupted. Some PGCs fail to migrate from the endoderm to the mesoderm. Many of those that do fail to associate with the gonadal mesoderm and remain scattered throughout the embryo. Gonadal mesoderm development proceeds normally, as does development of the nervous system and the trachea.

      (Van Doren et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Hmgcrclb2 is a suppressor of adult brain phenotype of SNF4Aγloe

      (Tschäpe et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The addition of Hmgcrclb2 to SNF4Aγloe animals shows a small but significant reduction in the number of holes seen in the adult brain.

      (Tschäpe et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Strong allele.

      (Van Doren and Lehmann, 2001.2.14)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      26.31
      (Van Doren and Lehmann, 2001.2.14)
      HMGCRclb26.31
      (Yi, 2006, Yi et al., 2006)
      Hmgcrclb2
      clb26.31
      (Tschäpe et al., 2002)
      hmgcrclb2
      (Van Doren et al., 1998)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)