FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Hmgcrclb1
Open Close
General Information
Symbol
Dmel\Hmgcrclb1
Species
D. melanogaster
Name
FlyBase ID
FBal0094692
Feature type
allele
Associated gene
Dmel\Hmgcr
Associated Insertion(s)
Carried in Construct
Also Known As
clb11.54
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Yi et al., 2006)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G841A.

(Van Doren and Lehmann, 2001.2.14)

Co-ordinates refer to the pNB36C cDNA.

(Van Doren and Lehmann, 2001.2.14)

Amino acid replacement: W91term.

(Van Doren and Lehmann, 2001.2.14)

An early nonsense mutation.

(Van Doren et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:23,747,416..23,747,416 [+]
Nucleotide change:

G23747416A

Reported nucleotide change:

G841A

Amino acid change:

W91term | Hmgcr-PA

Reported amino acid change:

W91term

(Van Doren and Lehmann, 2001.2.14, Goodman and Chang, 1985)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  neurodegenerative disease
      modeled by SNF4Aγloe
      (Tschäpe et al., 2002)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The posterior region of the heart tube is abnormally dilated in mutant embryos.

      (Yi et al., 2006)

      In Hmgcrclb1 homozygous embryos, 10 germ cells on average fail to migrate into the mesoderm. Females in which the germ-line is homozygous for Hmgcrclb1 are sterile.

      (Santos and Lehmann, 2004)

      Some germ cells fail to move off the midgut and do not associate with somatic gonadal precursor cells in the mesoderm at stages 11-12 in mutant embryos.

      (Stein et al., 2002)

      Primordial germ cell migration is disrupted. Some PGCs fail to migrate from the endoderm to the mesoderm. Many of those that do fail to associate with the gonadal mesoderm and remain scattered throughout the embryo. Gonadal mesoderm development proceeds normally, as does development of the nervous system and the trachea.

      (Van Doren et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Hmgcrclb1 is a suppressor of adult brain phenotype of SNF4Aγloe

      (Tschäpe et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The germ cell migration defects of slamwaldo1 Hmgcrclb1 double mutants are stronger than either single mutant; no germ cells move off the midgut in double mutant embryos.

      (Stein et al., 2002)

      The addition of Hmgcrclb1 to SNF4Aγloe animals shows a small but significant reduction in the number of holes seen in the adult brain.

      (Tschäpe et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Strong allele.

      (Van Doren and Lehmann, 2001.2.14)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      11.54
      (Van Doren and Lehmann, 2001.2.14)
      HMGCRclb11.54
      (Yi, 2006, Yi et al., 2006)
      Hmgcrclb1
      clb11.54
      (Kenwrick et al., 2019, Tschäpe et al., 2002)
      hmgcrclb1
      (Wawersik et al., 2005, Van Doren et al., 1998)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)