FlyBase Allele Report: Dmel\CycB[3]

General Information

Symbol

Dmel\CycB³

Species

D. melanogaster

Name

FlyBase ID

FBal0094854

Feature type

allele

Associated gene

Dmel\CycB

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

loss of function allele

(Jacobs et al., 1998)

Mutagen

Delta2-3 transposase

(Jacobs et al., 1998)

Progenitor genotype

CycB¹

(Jacobs et al., 1998)

Cytology

Description

Imprecise excision of P-element resulting in small deletion removing the region encoding α-helix 1, a conserved element of the cyclin box.

(Jacobs et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile

(Jacobs et al., 1998)

male sterile

(Jacobs et al., 1998)

viable

(Jacobs et al., 1998)

Phenotype Manifest In

embryonic abdominal segment (with CycB²), with CycB^2xNRE.hb

(Kadyrova et al., 2007)

filzkorper (with CycB²), with CycB^2xNRE.hb

(Kadyrova et al., 2007)

ovary

(Jacobs et al., 1998)

Detailed Description

Statement

Reference

Over 95% of embryos derived from CycB²/CycB³ ; CycB^2xNRE.hb females have defects in the abdominal segments, the posterior terminalia, or both. In extreme cases, the embryos die with an open posterior hole and not segments following the third thoracic one. The defects appear to arise during nuclear cleavage cycles 9-13; the somatic nuclei in the posterior of the embryos delay progression through cycles 9-13 and ultimately lose contact with the embryonic cortex, falling into the interior.

(Kadyrova et al., 2007)

Mutant females have rudimentary ovaries and lay few eggs. Homozygotes and hemizygotes reach adulthood.

(Jacobs et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

CycB3³, CycB³ has lethal phenotype

(Jacobs et al., 1998)

CycB3², CycB³ has lethal phenotype

(Jacobs et al., 1998)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

CycB³/CycB¹ is rescued by CycB^5A.UASp.GFP

(Mathieu et al., 2013)

CycB³ is rescued by CycB^+t10

(Jacobs et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

CycB³

(Mathieu et al., 2013, Althoff et al., 2009, Kadyrova et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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