FB2026_02 , released June 18, 2026
Allele: Dmel\sdUAS.cVa
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General Information
Symbol
Dmel\sdUAS.cVa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Varadarajan
FlyBase ID
FBal0095210
Feature type
allele
Associated gene
Dmel\sd
Associated Insertion(s)
Carried in Construct
P{UAS-sd.V}
Also Known As
UAS-sd
Key Links
Transgenic product class
cDNA
(Varadarajan and VijayRaghavan, 1999)
wild_type
(Varadarajan and VijayRaghavan, 1999)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Varadarajan and VijayRaghavan, 1999)
wild_type
(Varadarajan and VijayRaghavan, 1999)
Mutagen
in vitro construct
(Varadarajan and VijayRaghavan, 1999)
Progenitor genotype
Carried in construct
P{UAS-sd.V}
Cytology
Description

A sd cDNA (the E21 transcript) is expressed under the control of UAS regulatory sequences.

(Varadarajan and VijayRaghavan, 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
sd
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing sdScer\UAS.cVa under the control of Scer\GAL4vg.int2.1 in an otherwise wild-type background show wing defects; 40% have a "mild" phenotype (wings are significantly reduced, few veins and crossveins are still distinguishable), 47.5% have a "severe" phenotype (wing blade growth is severely impaired) and 12.5% have an "extreme" phenotype (thorax flight appendages are completely missing and no hinge structures are present).

      The severity of wing defects caused by expression of sdScer\UAS.cVa under the control of Scer\GAL4vg.int2.1 is suppressed by sd58/+; in the double mutant flies 61% have a "mild" phenotype (wings are significantly reduced, few veins and crossveins are still distinguishable), 34% have a "severe" phenotype (wing blade growth is severely impaired) and 5% have an "extreme" phenotype (thorax flight appendages are completely missing and no hinge structures are present).

      (Legent et al., 2006)

      The shape of the wing disc is distorted in animals expressing sdScer\UAS.cVa under the control of Scer\GAL4dpp.blk1. The size and shape of the wing disc is abnormal in animals expressing sdScer\UAS.cVa under the control of Scer\GAL4ptc-559.1. Ectopic wing outgrowth from wing derived tissue is seen in approximately 10% of cases. The wing disc has a smaller notal region than wild-type in animals expressing sdScer\UAS.cVa under the control of Scer\GAL4vg.int2.1. Adults derived from these animals have wing blade defects but the notum is not affected.

      (Varadarajan and VijayRaghavan, 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Scer\GAL4vg.int2.1, sdUAS.cVa has visible phenotype, enhanceable by vg[+]/vgnull

      (Legent et al., 2006)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Scer\GAL4vg.int2.1, sdUAS.cVa has wing phenotype, enhanceable by vg[+]/vgnull

      (Legent et al., 2006)

      Scer\GAL4vg.int2.1, sdUAS.cVa has wing blade phenotype, enhanceable by vg[+]/vgnull

      (Legent et al., 2006)

      Scer\GAL4vg.int2.1, sdUAS.cVa has wing hinge phenotype, enhanceable by vg[+]/vgnull

      (Legent et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The severity of wing defects caused by expression of sdScer\UAS.cVa under the control of Scer\GAL4vg.int2.1 is enhanced by vgnull/+; in the double mutant flies 93% have an "extreme" phenotype (thorax flight appendages are completely missing and no hinge structures are present) and 7% have a "severe" phenotype (wing blade growth is severely impaired).

      (Legent et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      sdScer\UAS.cVa
      sdUAS.cVa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Varadarajan
      (Varadarajan and VijayRaghavan, 1999)
      Secondary FlyBase IDs
        References (3)