FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\disco-rbae-1
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General Information
Symbol
Dmel\disco-rbae-1
Species
D. melanogaster
Name
FlyBase ID
FBal0095516
Feature type
allele
Associated gene
Dmel\disco-r
Associated Insertion(s)
Carried in Construct
Also Known As
bae
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Mutation resulting in mis-expression of disco-r in certain neurons of the subesophageal ganglion. Lesion does not lie within the coding region.

    (Kiger, 2016.10.31)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Mutants fail to expand their wings following eclosion. The epithelial-mesenchymal transition (EMT) is blocked in the mutant wings following eclosion, but chromatin condensation and elimination of nuclei still proceeds.

        (Natzle et al., 2008)

        Delamination does not occur in bae1 mutant wings. Even a whole day after eclosion, a bae1/Y wing shows no delamination.

        (Kiger et al., 2007)

        Homozygous flies never expand their wings after eclosion. About 5% of heterozygous females also exhibit the phenotype. There are no apparent structural defects in mutant wings. In gynandromorph studies, the wing phenotype is found to be non-autonomous, and that either both wings have the phenotype or neither.

        (Kiger et al., 2001)

        Wings uninflated.

        (Green, 1999.2.6)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        NOT Enhanced by
        Statement
        Reference

        disco-rbae-1 has wing phenotype, non-enhanceable by panUAS.cWa/Scer\GAL430A

        (Kiger et al., 2001)
        NOT suppressed by
        Statement
        Reference

        disco-rbae-1 has wing phenotype, non-suppressible by panUAS.cWa/Scer\GAL430A

        (Kiger et al., 2001)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Mosaic analysis using the P-Repressor encoded by P{P-Sal}89D to repress expression of Pka-C1Scer\UAS.cKa under the control of Scer\GAL430A indicates that Pka-C1Scer\UAS.cKa must be expressed for the lethal interaction between bae1 and Pka-C1Scer\UAS.cKa expressed under the control of Scer\GAL430A to take place.

        (Kiger and Ho, 2001)

        The addition of bae1 to Pka-C1Scer\UAS.cKa, Scer\GAL430A flies is lethal. The addition of panScer\UAS.cWa (driven by Scer\GAL430A) has no effect on the bae1 phenotype.

        (Kiger et al., 2001)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer

        Discovered by M.M.Green in a laboratory stock on April 22 1968.

        (Kiger et al., 2001)
        Comments
        Comments

        Wing mutant phenotype is non-autonomous in gynanders and fate maps to the head.

        (Green, 1999.2.6)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        bae
        (Natzle et al., 2008, Kiger and Ho, 2001)
        bae1
        (Kiger, 2016.10.31)
        disco-rbae-1
        (Kiger, 2016.10.31)
        Name Synonyms
        baetone
        (Kiger et al., 2007)
        Secondary FlyBase IDs
          References (6)