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General Information
Symbol
Dmel\disco-rbae-1
Species
D. melanogaster
Name
FlyBase ID
FBal0095516
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
bae
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Mutation resulting in mis-expression of disco-r in certain neurons of the subesophageal ganglion. Lesion does not lie within the coding region.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Mutants fail to expand their wings following eclosion. The epithelial-mesenchymal transition (EMT) is blocked in the mutant wings following eclosion, but chromatin condensation and elimination of nuclei still proceeds.

    Delamination does not occur in bae1 mutant wings. Even a whole day after eclosion, a bae1/Y wing shows no delamination.

    Homozygous flies never expand their wings after eclosion. About 5% of heterozygous females also exhibit the phenotype. There are no apparent structural defects in mutant wings. In gynandromorph studies, the wing phenotype is found to be non-autonomous, and that either both wings have the phenotype or neither.

    Wings uninflated.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    NOT Enhanced by
    Statement
    Reference

    disco-rbae-1 has wing phenotype, non-enhanceable by panUAS.cWa/Scer\GAL430A

    NOT suppressed by
    Statement
    Reference

    disco-rbae-1 has wing phenotype, non-suppressible by panUAS.cWa/Scer\GAL430A

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Mosaic analysis using the P-Repressor encoded by P{P-Sal}89D to repress expression of Pka-C1Scer\UAS.cKa under the control of Scer\GAL430A indicates that Pka-C1Scer\UAS.cKa must be expressed for the lethal interaction between bae1 and Pka-C1Scer\UAS.cKa expressed under the control of Scer\GAL430A to take place.

    The addition of bae1 to Pka-C1Scer\UAS.cKa, Scer\GAL430A flies is lethal. The addition of panScer\UAS.cWa (driven by Scer\GAL430A) has no effect on the bae1 phenotype.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer

    Discovered by M.M.Green in a laboratory stock on April 22 1968.

    Comments
    Comments

    Wing mutant phenotype is non-autonomous in gynanders and fate maps to the head.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (4)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (6)