FlyBase Allele Report: Dmel\Doa[unspecified]

General Information

Symbol

Dmel\Doa^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0095820

Feature type

allele

Associated gene

Dmel\Doa

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal sex-determination | female | recessive

(Du et al., 1998)

lethal (with Doa^12-44)

(Morris et al., 2003)

lethal (with Doa^198-14)

(Morris et al., 2003)

Phenotype Manifest In

female genitalia

(Du et al., 1998)

female terminalia sensillum

(Du et al., 1998)

Detailed Description

Statement

Reference

XX ; Doa^unspecified/Doa^Dem adults have subtle intersexual characteristics in sex combs, pigmentation and genitalia. Female-specific vaginal bristles are missing or irregular in most cases. Doa^unspecified/Doa⁷ adults have subtle intersexual characteristics. XY flies carrying tra^Hsp83.PS develop phenotypically as nearly perfect females. This female differentiation is substantially reversed if the flies are also carrying Doa^unspecified/Doa^Dem.

(Du et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Doa^unspecified/Doa^Dem is a suppressor of abnormal sex-determination | male phenotype of tra^Hsp83.PS

(Du et al., 1998)

Other

Statement

Reference

Doa^unspecified, tra^unspecified has abnormal sex-determination | female phenotype

(Du et al., 1998)

Doa⁷/Doa^unspecified, tra2^B has abnormal sex-determination | dominant | female phenotype

(Du et al., 1998)

Doa^unspecified, tra2^B has abnormal sex-determination | female phenotype

(Du et al., 1998)

Doa⁷/Doa^unspecified, tra^unspecified has abnormal sex-determination | dominant | female phenotype

(Du et al., 1998)

Doa^unspecified/Doa^Dem, tra^unspecified has abnormal sex-determination | dominant | female phenotype

(Du et al., 1998)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Doa^unspecified is a non-suppressor of phenotype of w^hd81b6

(Rabinow and Birchler, 1990)

Doa^unspecified is a non-suppressor of phenotype of w^hd81b11

(Rabinow and Birchler, 1990)

Doa^unspecified is a non-suppressor of phenotype of w^hd81b25

(Rabinow and Birchler, 1990)

Doa^unspecified is a non-suppressor of phenotype of w^ric

(Rabinow and Birchler, 1990)

Other

Statement

Reference

Doa^unspecified, tra^unspecified has female genitalia phenotype

(Du et al., 1998)

Doa^unspecified/Doa^Dem, tra^unspecified has leg | female phenotype

(Du et al., 1998)

Doa^unspecified/Doa^Dem, tra^unspecified has abdominal tergite | female phenotype

(Du et al., 1998)

Doa⁷/Doa^unspecified, tra2^B has leg | female phenotype

(Du et al., 1998)

Doa^unspecified, tra^unspecified has leg | female phenotype

(Du et al., 1998)

Doa^unspecified, tra^unspecified has abdominal tergite | female phenotype

(Du et al., 1998)

Doa^unspecified, tra2^B has leg | female phenotype

(Du et al., 1998)

Doa⁷/Doa^unspecified, tra^unspecified has leg | female phenotype

(Du et al., 1998)

Doa^unspecified/Doa^Dem, tra^unspecified has female genitalia phenotype

(Du et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygous tra^unspecified/+ adults have normal sexual differentiation. XX ; tra^unspecified/+ adults that are also carrying either Doa^unspecified/Doa^Dem or Doa^unspecified/Doa⁷ are clearly intersexual with respect to the number or morphology of sex combs. XX ; Doa^unspecified tra^unspecified/Doa^Dem + adults have genitalia which have characteristics of both sexes, including male-like clasper bristles and anal pads. Pigmentation of abdominal tergites is intermediate to that of the normal male and female phenotypes. Heterozygous tra2^B/+ adults have normal sexual differentiation. XX ; tra2^B/+ adults that are also carrying Doa^unspecified/Doa⁷ are clearly intersexual with respect to the number or morphology of sex combs.

(Du et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Doa^unspecified

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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