FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\eIF4A1069
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General Information
Symbol
Dmel\eIF4A1069
Species
D. melanogaster
Name
FlyBase ID
FBal0096981
Feature type
allele
Associated gene
Dmel\eIF4A
Associated Insertion(s)
P{lacW}eIF4A1069
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gao et al., 2000, Galloni and Edgar, 1999)
Progenitor genotype
Associated Insertion(s)
P{lacW}eIF4A1069
Cytology
Description

Insertion into the first intron of eIF-4a.

(Galloni and Edgar, 1999)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant eIF-4a1069 clones are smaller than wild-type, but have wild-type cell size.

      (Gao et al., 2000)

      Larval growth arrest, in L2. 60% survive until 4 days after hatching. 42% survive until 8 days after hatching. DNA replication continues at a reduced level compared to wild type. Mutant phenotype is cell autonomous. Mutant clones in the wing disc are detectable but never reach twin spot size. Flies which have had clones induced in them do not show a rough eye phenotype.

      (Galloni and Edgar, 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      eIF4A1069 is a suppressor of increased cell number | somatic clone phenotype of Ptendj189

      (Gao et al., 2000)
      NOT Suppressor of
      Statement
      Reference

      eIF4A1069 is a non-suppressor of increased cell size | somatic clone phenotype of Ptendj189

      (Gao et al., 2000)
      Phenotype Manifest In
      Other
      Statement
      Reference

      Ptendj189, eIF4A1069 has eye disc | somatic clone phenotype

      (Gao et al., 2000)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      eIF4AYE9

      (Li et al., 2005)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Excision of the P-element is accompanied by reversion of the mutant phenotype.

      (Galloni and Edgar, 1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      eIF-4a1069
      eIF4A1069
      (Li et al., 2005)
      eif4A1069
      (Galloni and Edgar, 1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)