FlyBase Allele Report: Dmel\kn[col-3]

General Information

Symbol

Dmel\kn^col-3

Species

D. melanogaster

Name

FlyBase ID

FBal0097025

Feature type

allele

Associated gene

Dmel\kn

Associated Insertion(s)

Carried in Construct

Also Known As

col³

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Crozatier and Vincent, 1999)

Mutagen

ethyl methanesulfonate

(Crozatier et al., 1999)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | late embryonic stage (with kn^col-1)

(Stratmann et al., 2019)

lethal | recessive

(Crozatier et al., 1999)

Phenotype Manifest In

apterous-expressing neuron of the lateral cluster of the thorax | late embryonic stage (with kn^col-1)

(Stratmann et al., 2019)

cephalopharyngeal skeleton

(Crozatier et al., 1999)

embryonic head

(Crozatier and Vincent, 1999)

larval somatic muscle cell

(Crozatier and Vincent, 1999)

lateral process of cephalopharyngeal skeleton

(Crozatier et al., 1999)

muscle cell of abdominal 1 dorsal acute muscle 3

(Crozatier and Vincent, 1999)

muscle cell of abdominal 2 dorsal acute muscle 3

(Crozatier and Vincent, 1999)

muscle cell of abdominal 3 dorsal acute muscle 3

(Crozatier and Vincent, 1999)

muscle cell of abdominal 4 dorsal acute muscle 3

(Crozatier and Vincent, 1999)

muscle cell of abdominal 5 dorsal acute muscle 3

(Crozatier and Vincent, 1999)

muscle cell of abdominal 6 dorsal acute muscle 3

(Crozatier and Vincent, 1999)

muscle cell of abdominal 7 dorsal acute muscle 3

(Crozatier and Vincent, 1999)

muscle cell of mesothoracic dorsal acute muscle 4

(Crozatier and Vincent, 1999)

muscle cell of metathoracic dorsal acute muscle 4

(Crozatier and Vincent, 1999)

Detailed Description

Statement

Reference

In kn^col-1/kn^col-3 embryos ap-expressing neurons fail to project their axons into the medial-most Fas2-immunopositive fascicle in the ventral nerve cord. Their commissural (but not lateral) projections are also impaired.

(Stratmann et al., 2019)

The number of SE2 neurons is normal in kn^col-1/kn^col-3 mutant animals.

(Losada-Pérez et al., 2010)

Muscle DA3^A/DA4^T is missing or (in a few cases) reduced to a thinned muscle. This phenotype is highly penetrant and specific.

(Crozatier and Vincent, 1999)

Lethality occurs during the late embryonic to first larval instar stage. Homozygous and hemizygous embryos have head defects; the ventral arms are missing and the lateralgraten are reduced. The T-ribs in the floor of the pharynx, and the antennal, maxillary or hypopharyngeal sensory organs are present and a normal pattern of internal sensory structures is seen. The embryos that hatch do not grow and tend to crawl out of the medium, suggesting that they are unable to feed.

(Crozatier et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

kn^col-3 is rescued by kn^+m5

(Crozatier and Vincent, 1999)

kn^col-3 is rescued by kn^+m5

(Crozatier et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

col³

(Stratmann et al., 2019, Stratmann and Thor, 2017, Gabilondo et al., 2016, Losada-Pérez et al., 2013, Benito-Sipos et al., 2011, Karlsson et al., 2010, Losada-Pérez et al., 2010, Baumgardt et al., 2007, Crozatier and Vincent, 1999, Crozatier et al., 1999, Vervoort et al., 1999)

kn^col-3

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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