FlyBase Allele Report: Dmel\sls[S000201]

General Information

Symbol

Dmel\sls^S000201

Species

D. melanogaster

Name

FlyBase ID

FBal0097088

Feature type

allele

Associated gene

Dmel\sls

Associated Insertion(s)

P{lacW}sls^S000201

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Zhang et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{lacW}sls^S000201

Cytology

Description

P{lacW} insertion in the first intron upstream of the start codon.

(Zhang et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | embryonic stage | recessive

(Zhang et al., 2000)

lethal | recessive

(Zhang et al., 2000)

Phenotype Manifest In

visceral muscle fiber | embryonic stage

(Zhang et al., 2000)

Detailed Description

Statement

Reference

Mutants die at the pupal/pharate adult stage. Mutant embryos show grossly normal morphology, normal segmentation, normal epidermal denticle belts and normal patterning of the neuromusculature. They show greatly reduced movement compared to wild-type. Mature embryos show striking defects in individual muscle fibre morphology.

(Zhang et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

sls^B170

(Zhang et al., 2000)

sls^B173

(Zhang et al., 2000)

sls^B247

(Zhang et al., 2000)

sls^B68

(Zhang et al., 2000)

sls^C872

(Zhang et al., 2000)

sls^C995

(Zhang et al., 2000)

sls^j1D7

(Zhang et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Excision of the P{lacW} element can give viable revertants. Based on the lethal stage and antibody staining, sls alleles form the series: sls^S000201 (weakest), sls^B173, sls^C995, sls^j1D7, sls^B68, sls^C872 (strongest).

(Zhang et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

20/01

(Zhang et al., 2000)

Ket^S000201

Titin^S000201

l(3)S02001

(Zhang et al., 2000)

sls^S000201

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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