FlyBase Allele Report: Dmel\B-H2[UAS.cSa]

General Information

Symbol

Dmel\B-H2^UAS.cSa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Sato

FlyBase ID

FBal0097407

Feature type

allele

Associated gene

Dmel\B-H2

Associated Insertion(s)

Carried in Construct

P{UAS-B-H2.S}

Also Known As

UAS-BarH2, UAS-BarH2^F11

Key Links

Transgenic product class

cDNA

(Sato et al., 1999)

wild_type

(Sato et al., 1999)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Sato et al., 1999)

wild_type

(Sato et al., 1999)

Mutagen

in vitro construct

(Sato et al., 1999)

Progenitor genotype

Carried in construct

P{UAS-B-H2.S}

Cytology

Description

Expression of B-H2 2.2kb cDNA is governed by UAS regulatory sequences.

(Sato et al., 1999)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

B-H2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^ap-md544

(Kojima et al., 2000)

visible, with Scer\GAL4^ey.PB

(Kumar and Moses, 2001)

Phenotype Manifest In

eye, with Scer\GAL4^ey.PB

(Kumar and Moses, 2001)

eye disc morphogenetic furrow, with Scer\GAL4^dpp.blk1

(Lim and Choi, 2003, Kumar and Moses, 2001)

leg, with Scer\GAL4^ap-md544

(Kojima et al., 2000)

leg disc, with Scer\GAL4^dpp.blk1

(Kojima et al., 2000)

photoreceptor neuron, with Scer\GAL4^dpp.blk1

(Lim and Choi, 2003)

Detailed Description

Statement

Reference

When B-H2^Scer\UAS.cSa is driven by Scer\GAL4^lz-gal4 in the eye disc, furrow migration is blocked and photoreceptor differentiation is eliminated.

(Lim and Choi, 2003)

Expression of B-H2^Scer\UAS.cSa under the control of Scer\GAL4^ey.PB results in deletion of the eye.

(Kumar and Moses, 2001)

Expression of B-H2^Scer\UAS.cSa under the control of Scer\GAL4^dpp.blk1 blocks furrow formation in the eye disc.

(Kumar and Moses, 2001)

Overexpression of B-H2^Scer\UAS.cSa under the control of Scer\GAL4^dpp.blk1 results in ectopic fold formation in the leg disc. The formation of the endogenous central fold is interrupted. Overexpression of B-H2^Scer\UAS.cSa under the control of Scer\GAL4^ap-md544 gives similar leg phenotypes to those seen when B-H1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^ap-md544.

(Kojima et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

B-H2^UAS.cSa/Scer\GAL4^lz-gal4 partially rescues Df(1)Bar

(Lim and Choi, 2003)

Scer\GAL4^{B-H1.B4.5.B-H2.S8}/B-H2^UAS.cSa partially rescues Df(1)BH2

(Sato et al., 1999)

Comments

Scer\GAL4^{B-H1.B4.5.B-H2.S8}-driven expression of B-H2^Scer\UAS.cSa rescues the microchaetae phenotype but not the PS macrochaetae phenotype of Df(1)BH2.

(Sato et al., 1999)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

B-H2^Scer\UAS.cSa

B-H2^UAS.cSa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Sato

(Sato et al., 1999)

Secondary FlyBase IDs

References (8)

Report Sections

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