FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Syx1AH3-N
Open Close
General Information
Symbol
Dmel\Syx1AH3-N
Species
D. melanogaster
Name
FlyBase ID
FBal0099812
Feature type
allele
Associated gene
Dmel\Syx1A
Associated Insertion(s)
Carried in Construct
P{syx1AH3-N}
Key Links
Transgenic product class
inframe_deletion
(Wu et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Wu et al., 1999)
Mutagen
in vitro construct
(Wu et al., 1999)
Progenitor genotype
Syx1A+t13.5
(Wu et al., 1999)
Carried in construct
P{syx1AH3-N}
Cytology
Description

A deletion removes the majority of the N-terminal region of the H3 domain (amino acids 204-250).

(Wu et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
Syx1A
Encoded product / tool
Syx1A
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In contrast with wild-type, Syx1AΔ229 and Syx1A06737 flies rescued with Syx1AH3-N, undergo no peristaltic muscle contractions prior to hatching, nor show any response to tactile stimulation. In Syx1AΔ229 embryos rescued with Syx1AH3-N (as in Syx1AΔ229 embryos) no denticle belts are seen. Using whole-cell patch-clamp analysis, in Syx1AH3-N mutants in a Syx1AΔ229 null background, evoked and spontaneous neurotransmission is abolished. Postsynaptic muscles respond normally to neurotransmitter.

      (Wu et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Syx1AH3-N fails to rescue Syx1AΔ229

      (Wu et al., 1999)

      Syx1AH3-N fails to rescue Syx1A06737

      (Wu et al., 1999)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Syx1AH3-N
      syx1AH3-N
      syxH3-N
      (Wu et al., 1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)