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General Information
Symbol
Dmel\Syx1AH3-N
Species
D. melanogaster
Name
FlyBase ID
FBal0099812
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

A deletion removes the majority of the N-terminal region of the H3 domain (amino acids 204-250).

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In contrast with wild-type, Syx1AΔ229 and Syx1A06737 flies rescued with Syx1AH3-N, undergo no peristaltic muscle contractions prior to hatching, nor show any response to tactile stimulation. In Syx1AΔ229 embryos rescued with Syx1AH3-N (as in Syx1AΔ229 embryos) no denticle belts are seen. Using whole-cell patch-clamp analysis, in Syx1AH3-N mutants in a Syx1AΔ229 null background, evoked and spontaneous neurotransmission is abolished. Postsynaptic muscles respond normally to neurotransmitter.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to rescue
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Syx1AH3-N
syx1AH3-N
Name Synonyms
Secondary FlyBase IDs
    References (1)