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General Information
Symbol
Dmel\Syx1A06737
Species
D. melanogaster
Name
FlyBase ID
FBal0044376
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Psyx
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The P{PZ}Syx1A06737 insertion maps within both Syx1A and 4EHP (nested genes).

P-element insertion 880bp upstream of the translation start site.

Insertion components
P{PZ}Syx1A06737
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous embryos do not exhibit cuticle defects. Germline clones produce eggs with poorly differentiated cuticle.

Mutation compromises neurotransmission at the embryonic neuromuscular junction. Mature embryos fail to exhibit contraction waves but do emerge from the egg case. Cuticular structures are normal. Syx1A06737/Syx1A15ts transheterozygotes give progeny that exhibit reduced viability, rough eyes (disrupted ommatidial array, ommatidia may be missing, fused, improperly rotated or misaligned) and notching along the posterior margin of the wing. Clones cannot be recovered in the eye as lack of Syx1A activity in cells of the developing eye causes lethality.

Embryos do not exhibit typical peristaltic construction waves and reduced movements of the mouth hooks and muscles in the head region. Embryos were also unable to clear their tracheal system of fluid. Endogenous transmission is blocked but spontaneous vesicle release continues. The ability of vesicles to fuse and release neurotransmitter in response to calcium ion stimulus is impaired, reflected by the severely reduced excitatory junction current.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

A. Spradling.

Comments
Comments

Lethality can be reverted by precise excision of the P-element.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (10)
Reported As
Name Synonyms
Secondary FlyBase IDs
  • FBal0009575
References (13)