FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mir-279S096207
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General Information
Symbol
Dmel\mir-279S096207
Species
D. melanogaster
Name
FlyBase ID
FBal0099967
Feature type
allele
Associated gene
Dmel\mir-279
Associated Insertion(s)
P{lacW}mir-279S096207
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Deak et al., 1997)
P-element activity
(Szeged Stock Center, 1998-)
Progenitor genotype
Associated Insertion(s)
P{lacW}mir-279S096207
Cytology
Description

Insertion approximately 1kb upstream of mir-279.

(Cayirlioglu et al., 2008)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous clones induced by the eyFLP method result in ectopic CO[[2]] neurons on the maxillary palp (MP). The ectopic neurons show dual targeting specificity: in addition to targeting the V-glomerulus they also innervate a set of medial glomeruli normally innervated by two MP olfactory receptor neuron classes. The number of antennal CO[[2]] neurons is unaffected.

      (Hartl et al., 2011)

      Approximately 50% of egg chambers from induced mir-279S096207 clones exhibit ectopic cells or clusters of cells. The number of border cells within the main cluster remains normal, indicating the abnormal invasion of follicle cells.

      mir-279S096207 mutant egg chambers exhibit frequent border-cell migration defects.

      (Yoon et al., 2011)

      Mutants show no defects in targeting of the DL1 glomerulus in the antennal lobe.

      (Berdnik et al., 2008)

      The maxillary palps of mutant flies are sensitive to CO[[2]], showing a detectable electropalpogram response to CO[[2]] (in contrast to control flies where the maxillary palps do not show a detectable response to CO[[2]] in this assay).

      The maxillary palps contain ectopic Gr21a-expressing neurons in mutant flies. These ectopic maxillary palp neurons target the V-glomerulus and other medial sites in the antennal lobe. The wiring specificity of mutant antennal CO[[2]] sensing neurons is identical in mutant and wild-type flies.

      Individual sensilla in mutant maxillary palps contain additional neurons compared to wild-type maxillary palp sensilla.

      (Cayirlioglu et al., 2008)

      Lethal phase is from the pharate adult stage onwards.

      (Deak et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of prosScer\UAS.cMa under the control of Scer\GAL4Act.PU suppresses the formation of ectopic CO[[2]] neurons on the maxillary palp caused by mir-279S096207 clones in 37% of animals.

      (Hartl et al., 2011)

      A Stat92EEP3391 heterozygous background suppresses the ectopic invasive cell phenotype and the border-cell migration defects found in mir-279S096207 mutant clones.

      (Yoon et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      mir-279S096207 is rescued by mir-279UAS.DsRed(Unk)/Scer\GAL4Act.PU

      (Hartl et al., 2011)

      mir-279S096207 is rescued by mir-279+t3

      (Yoon et al., 2011)

      mir-279S096207 is rescued by mir-279+t3

      (Cayirlioglu et al., 2008)
      Comments

      The presence of ectopic cells or clusters of cells in the egg chambers of mir-279S096207 mutant clones is ameliorated by the presence of mir-279+t3.

      (Yoon et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      0962/07
      (Deak et al., 1997)
      S0962-07
      (Cayirlioglu et al., 2008)
      l(3)S096207S096207
      miR-279962-7
      (Hartl et al., 2011)
      mir-279S096207
      Name Synonyms
      Secondary FlyBase IDs
        References (6)