FlyBase Allele Report: Dmel\Plc21C[A]

General Information

Symbol

Dmel\Plc21C^A

Species

D. melanogaster

Name

FlyBase ID

FBal0100414

Feature type

allele

Associated gene

Dmel\Plc21C

Associated Insertion(s)

Carried in Construct

Also Known As

plc21C^p60A

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Weinkove et al., 1999)

Progenitor genotype

P{lacW}Plc21C^k31911

(Weinkove et al., 1999)

Caused by aberration

Df(2L)Pi3K21B-A

Cytology

Description

Proximal break of Df(2L)Pi3K21B-A falls in the first intron of Plc21C, at the site of the P{lacW} insertion in the progenitor chromosome.

(Weinkove et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology (with Plc21C^k31911)

(Kain et al., 2008)

abnormal neurophysiology | dominant

(Kain et al., 2008)

Phenotype Manifest In

Detailed Description

Statement

Reference

Plc21C^A/+ has no effect on evoked neurotransmission.

(Brusich et al., 2015)

The electroantennograms of Plc21C^A/+ animals show a small but significant decrease in amplitude compared to controls in response to a number of odours (ethyl acetate, butanol, propionic acid, benzaldehyde and iso-amyl acetate).

The electroantennograms of Plc21C^k31911/Plc21C^A animals show a significant decrease in amplitude compared to controls in response to a number of odours (ethyl acetate, butanol, propionic acid, benzaldehyde and iso-amyl acetate).

(Kain et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Plc21C^A has abnormal neurophysiology | dominant phenotype, enhanceable by Galpha49B[+]/Gαq^221c

(Kain et al., 2008)

Plc21C^A has abnormal neurophysiology | dominant phenotype, enhanceable by Gα49B[+]/Gαq¹³⁷⁰

(Kain et al., 2008)

Enhancer of

Statement

Reference

Plc21C[+]/Plc21C^A is an enhancer | female limited of partially lethal - majority die phenotype of Scer\GAL4^elav-C155, cac^{RQ,SL.UAS.EGFP}

(Brusich et al., 2018)

Plc21C[+]/Plc21C^A is an enhancer of abnormal neurophysiology | dominant phenotype of Gαq^221c

(Kain et al., 2008)

Plc21C[+]/Plc21C^A is an enhancer of abnormal neurophysiology | dominant phenotype of Gαq¹³⁷⁰

(Kain et al., 2008)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

One copy of Plc21C^A does not prevent the compensatory increase in quantal content seen in the NMJs GluRIIA^SP16 mutant larvae that have reduced quantal size. Evoked neurotransmission is therefore unaffected.

(Brusich et al., 2015)

The electroantennograms of Gα49B^221c/Plc21C^A and Gα49B¹³⁷⁰/Plc21C^A double heterozygous animals show a significant decrease in amplitude compared to controls in response to a number of odours (ethyl acetate, butanol, propionic acid, benzaldehyde and iso-amyl acetate) and the reduction in the double heterozygotes is significantly greater than that expected to arise from a mere additive effect of the single heterozygous phenotypes.

(Kain et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Plc21C^A

Plc21C^p60A

(Brusich et al., 2018, Brusich et al., 2015)

plc21C^p60A

(Kain et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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