FlyBase Allele Report: Dmel\dsh[unspecified]

General Information

Symbol

Dmel\dsh^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0101448

Feature type

allele

Associated gene

Dmel\dsh

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity

(Gubb et al., 1999)

Phenotype Manifest In

tarsal segment 1 & joint

(Gubb et al., 1999)

tarsal segment 2 & joint

(Gubb et al., 1999)

tarsal segment 3

(Gubb et al., 1999)

tarsal segment 4

(Gubb et al., 1999)

triple row of wing sensilla

(Gubb et al., 1999)

wing

(Gubb et al., 1999)

wing hair

(Gubb et al., 1999)

Detailed Description

Statement

Reference

Mutant female germline stem cells are maintained normally in their niche.

(Song et al., 2002)

Triple row bristle phenotypes and wing blade polarity phenotypes are seen, similar to those seen in pk^pk-sple-13. The dsh^unspecified tarsal phenotype is similar to pk^pk-sple-13 in giving complete duplications of the T3 and T4 segments; an incipient joint in present in T1 and T2, but the external morphology of these segments remain normal.

(Gubb et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

dsh^unspecified is a suppressor of abnormal planar polarity | heat sensitive phenotype of fz^I.hs

(Winter et al., 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

dsh^unspecified has metatarsus phenotype, enhanceable by pk^sple-1

(Gubb et al., 1999)

dsh^unspecified, dsh^w has wing phenotype, enhanceable by wg^unspecified

(Theisen et al., 1994)

Suppressed by

Statement

Reference

dsh^unspecified has wing phenotype, suppressible by pk^sple-1

(Gubb et al., 1999)

dsh^unspecified has wing hair phenotype, suppressible by pk^sple-1

(Gubb et al., 1999)

Enhancer of

Statement

Reference

dsh^unspecified is an enhancer of abdominal sternite bristle phenotype of Mmus\Nkd1^UAS.Tag:MYC, Scer\GAL4^B119

(Wharton et al., 2001)

dsh^unspecified is an enhancer of leg phenotype of Mmus\Nkd1^UAS.Tag:MYC, Scer\GAL4^B119

(Wharton et al., 2001)

dsh^unspecified is an enhancer of metatarsus phenotype of pk^sple-1

(Gubb et al., 1999)

Suppressor of

Statement

Reference

dsh^unspecified is a suppressor of wing hair phenotype of fz^I.hs

(Winter et al., 2001)

dsh^unspecified is a suppressor of wing phenotype of pk³⁰

(Gubb et al., 1999)

dsh^unspecified is a suppressor of wing hair phenotype of pk³⁰

(Gubb et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

dsh^unspecified suppresses the extreme triple row phenotype of pk³⁰ and pk^sple-1, to one that is phenotypically dsh^unspecified. The dsh^unspecified wing phenotype is also slightly, but consistently, reduced by pk^sple-1. The wing blade phenotype of pk³⁰/dsh^unspecified is intermediate between the two single mutants. The dsh^unspecified tarsal phenotype is unaffected by the addition of pk³⁰. There is a synergistic interaction between dsh^unspecified and pk^sple-1, with the double mutant giving a more extreme mirror image transformation of the T1 segment than either of the single mutants.

(Gubb et al., 1999)

If dsh^w,dsh^unspecified flies are also made heterozygous for a wg allele, the frequency of wg-like defects increases to 100%, including missing/reduced wings, duplicated nota, head defects and leg abnormalities.

(Theisen et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

dsh^unspecified is rescued by dsh^Tag:MYC

(Waldrop et al., 2006)

dsh^unspecified is rescued by dsh^+t7.5

(Theisen et al., 1994)

dsh^unspecified is rescued by dsh^+t7EX

(Theisen et al., 1994)

Partially rescued by

dsh^unspecified is partially rescued by dsh^w

(Theisen et al., 1994)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dsh^unspecified

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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