FlyBase Allele Report: Dmel\Rel[E38]

General Information

Symbol

Dmel\Rel^E38

Species

D. melanogaster

Name

FlyBase ID

FBal0101568

Feature type

allele

Associated gene

Dmel\Rel

Associated Insertion(s)

Carried in Construct

Also Known As

Relish^E38

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Hedengren et al., 1999)

Progenitor genotype

Rel^L3141a

(Hedengren, 1999.9.14, Hedengren et al., 1999)

Cytology

Description

Imprecise excision of the P{lacW} element, removing all four Rel transcription start sites.

(Hedengren et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurodegenerative disease

modeled by tefu^atm-8

(Petersen et al., 2013)

ameliorates retinal disease

modeled by norpA^EE5

(Chinchore et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response

(Guntermann et al., 2009, Hedengren et al., 1999)

abnormal immune response | adult stage

(Liu et al., 2018)

short lived

(Petersen et al., 2013)

short lived | conditional

(Liu et al., 2018)

Phenotype Manifest In

autophagosome | adult stage | conditional

(Liu et al., 2018)

Detailed Description

Statement

Reference

Rel^E38 homozygotes infected with ZIKV have a significantly shorter lifespan and have a significantly increased viral load, as compared to infected heterozygous controls; homozygotes infected with DCV do not show significant changes in viral load compared to infected controls; uninfected homozygotes and heterozygotes have comparable lifespans.

Unlike controls, Rel^E38 homozygotes fail to induce autophagy (assessed by Atg8-II levels in western blot) in response to infection by ZIKV.

(Liu et al., 2018)

Median survival in days is reduced in mutant flies compared to wild type.

(Petersen et al., 2013)

Mutant flies show a significantly reduced viability upon septic injury with E.coli compared to control flies.

(Guntermann et al., 2009)

Rel^E38 flies do not survive injection with E.cloacae β12 (injection with approximately 2 x 10⁵ bacteria per fly), dying within 27 hours, in contrast to wild-type flies. Lower doses of bacteria also kill the mutant flies (even at an average estimated dose of 0.2 bacteria per fly). Larvae show an efficient encapsulation reaction when infested with the parasitoid wasp L.boulardi. Total hemocyte cell number and morphology appears normal and the lymph glands are also not visibly affected. The phagocytic activity of hemocytes after injection with bacteria is indistinguishable from wild type.

(Hedengren et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Rel^E38 is a suppressor | partially of decreased size | adult stage phenotype of Df(3R)BSC519/asp^t25

(Mannino et al., 2023)

Rel^E38/Dif¹ is a suppressor | partially of decreased size | adult stage phenotype of Df(3R)BSC519/asp^t25

(Mannino et al., 2023)

Rel^E38 is a suppressor of decreased cell number | recessive | adult stage | progressive phenotype of vex^MI01691

(Davis et al., 2022)

Rel^E38/Rel^E20 is a suppressor of abnormal neuroanatomy | recessive | adult stage | progressive phenotype of dnr1^2-133

(Cao et al., 2013)

Rel^E38 is a suppressor of short lived phenotype of tefu^atm-8

(Petersen et al., 2013)

Rel^E38 is a suppressor of increased cell death | semidominant | adult stage phenotype of tefu^atm-8

(Petersen et al., 2013)

Rel^E38/Rel^E20 is a suppressor of abnormal neuroanatomy | adult stage | progressive | conditional phenotype of norpA^EE5

(Chinchore et al., 2012)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Rel^E38 is a non-enhancer of neuropil | adult stage phenotype of Df(3R)BSC519/asp^t25

(Mannino et al., 2023)

Rel^E38 is a non-enhancer of adult optic lobe neuron phenotype of Df(3R)BSC519/asp^t25

(Mannino et al., 2023)

Rel^E38 is a non-enhancer of medulla phenotype of Df(3R)BSC519/asp^t25

(Mannino et al., 2023)

Rel^E38/Dif¹ is a non-enhancer of neuropil | adult stage phenotype of Df(3R)BSC519/asp^t25

(Mannino et al., 2023)

Rel^E38/Dif¹ is a non-enhancer of adult optic lobe neuron phenotype of Df(3R)BSC519/asp^t25

(Mannino et al., 2023)

Rel^E38/Dif¹ is a non-enhancer of medulla phenotype of Df(3R)BSC519/asp^t25

(Mannino et al., 2023)

Suppressor of

Statement

Reference

Rel^E38 is a suppressor | partially of adult brain phenotype of Df(3R)BSC519/asp^t25

(Mannino et al., 2023)

Rel^E38/Dif¹ is a suppressor | partially of adult brain phenotype of Df(3R)BSC519/asp^t25

(Mannino et al., 2023)

Rel^E38 is a suppressor of dopaminergic PPL1 neuron | adult stage | decreased number phenotype of vex^MI01691

(Davis et al., 2022)

Rel^E38 is a suppressor of adult brain phenotype of vex^MI01691

(Davis et al., 2022)

Rel^E38 is a suppressor of adult dopaminergic neuron | decreased number phenotype of vex^MI01691

(Davis et al., 2022)

Rel^E38/Rel^E20 is a suppressor of adult brain | progressive phenotype of dnr1^2-133

(Cao et al., 2013)

Rel^E38/Rel^E20 is a suppressor of retina | progressive | conditional phenotype of norpA^EE5

(Chinchore et al., 2012)

NOT Suppressor of

Statement

Reference

Rel^E38 is a non-suppressor of neuropil | adult stage phenotype of Df(3R)BSC519/asp^t25

(Mannino et al., 2023)

Rel^E38 is a non-suppressor of adult optic lobe neuron phenotype of Df(3R)BSC519/asp^t25

(Mannino et al., 2023)

Rel^E38 is a non-suppressor of medulla phenotype of Df(3R)BSC519/asp^t25

(Mannino et al., 2023)

Rel^E38/Dif¹ is a non-suppressor of neuropil | adult stage phenotype of Df(3R)BSC519/asp^t25

(Mannino et al., 2023)

Rel^E38/Dif¹ is a non-suppressor of adult optic lobe neuron phenotype of Df(3R)BSC519/asp^t25

(Mannino et al., 2023)

Rel^E38/Dif¹ is a non-suppressor of medulla phenotype of Df(3R)BSC519/asp^t25

(Mannino et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Rel^E20/Rel^E38 significantly suppresses neurodegeneration in dnr1^2-133/dnr1^2-133 flies (measured at 29[o]C at 25 days old).

(Cao et al., 2013)

The median survival of tefu^atm-8 flies is significantly increased if they are also mutant for Rel^E38.

The increased apoptotic cell death seen in the brains of heterozygous and homozygous tefu^atm-8 adults is significantly suppressed if they are mutant for Rel^E38.

(Petersen et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

9458

w¹¹¹⁸; Rel^E38 e^s

Notes on Origin

Discoverer

Induced with: Nmdmc^E38.

(Hedengren et al., 1999)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AF186077

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

Rel38

(Libert et al., 2006)

Rel³⁸

(Davis et al., 2022)

Rel^E38

(Ahern-Djamali et al., 2025, Mannino et al., 2023, Pandey et al., 2023, Davis et al., 2022, Liu et al., 2022, Xiong et al., 2022, Petersen et al., 2013)

Rel^e38

(Clark et al., 2011)

Relish^E38

(Liu et al., 2018)

rel^E38

(Cao et al., 2013, Chinchore et al., 2012, Guntermann et al., 2009, Park et al., 2004)

relE38

(Wagner et al., 2021)

Name Synonyms

RelishE38

(Tanji et al., 2010)

relishE38

(Cao et al., 2013)

Secondary FlyBase IDs

References (19)

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