FlyBase Allele Report: Dmel\lncRNA:Hsrω[neo55]

General Information

Symbol

Dmel\lncRNA:Hsrω^neo55

Species

D. melanogaster

Name

FlyBase ID

FBal0101635

Feature type

allele

Associated gene

Dmel\lncRNA:Hsrω

Associated Insertion(s)

P{hsneo}lncRNA:Hsrω^neo55

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Cooley et al., 1988)

Progenitor genotype

Associated Insertion(s)

P{hsneo}lncRNA:Hsrω^neo55

Cytology

Description

The P{hsneo} insertion is 240bp upstream of the putative ATG start codon.

(Fernandez-Funez et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:21,296,501..21,296,501 [+]

(Fernandez-Funez et al., 2000, Cooley et al., 1988)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN1^82Q.UAS

(Fernandez-Funez et al., 2000)

modeled by Hsap\ATXN1^30Q.UAS

(Fernandez-Funez et al., 2000)

exacerbates olivopontocerebellar atrophy

modeled by Hsap\ATXN1^82Q.UAS

(Branco et al., 2008)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Hsrω^neo55 under the control of Scer\GAL4^GMR.PF does not result in a rough eye phenotype.

(Shulman and Feany, 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

lncRNA:Hsrω^neo55 is a non-enhancer of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

NOT Suppressor of

Statement

Reference

lncRNA:Hsrω^neo55 is a non-suppressor of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

lncRNA:Hsrω^neo55/Hsromega[+] is an enhancer of retina phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU

(Branco et al., 2008)

lncRNA:Hsrω^neo55 is an enhancer of eye phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

lncRNA:Hsrω^neo55 is an enhancer of retina phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

NOT Enhancer of

Statement

Reference

lncRNA:Hsrω^neo55/Hsromega[+] is a non-enhancer of retina phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Branco et al., 2008)

lncRNA:Hsrω^neo55 is a non-enhancer of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

NOT Suppressor of

Statement

Reference

lncRNA:Hsrω^neo55 is a non-suppressor of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

One copy of Hsrω^neo55 does not enhance the retinal phenotype seen when Hsap\HTT^{128Q.1-336.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PU.

One copy of Hsrω^neo55 enhances the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

(Branco et al., 2008)

The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is not modified if the flies are also carrying Hsrω^neo55.

(Shulman and Feany, 2003)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

The lethality of the "l(3)neo55" chromosome is separable from the P{hsneo}Hsrω^neo55 insertion. Separable from: l(3)neo55¹.

(Cooley et al., 1988)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Hsrω^neo55

(Branco et al., 2008)

l(3)neo55

(Shulman and Feany, 2003)

lncRNA:Hsrω^neo55

v(3)neo55

(Beaton, 1999.12.12)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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