FlyBase Allele Report: Dmel\GstS1[k09303]

General Information

Symbol

Dmel\GstS1^k09303

Species

D. melanogaster

Name

FlyBase ID

FBal0101655

Feature type

allele

Associated gene

Dmel\GstS1

Associated Insertion(s)

P{lacW}GstS1^k09303

Carried in Construct

Also Known As

Gst2^k09303

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Singh et al., 2001, Fernandez-Funez et al., 2000, Spradling, 1999.12.9, Spradling et al., 1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}GstS1^k09303

Cytology

Description

Insertion of P{lacW} between bases 29 and 30 of the transcript, in the 5' UTR.

(Singh et al., 2001)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:17,097,399..17,097,399 [+]

(Singh et al., 2001, Fernandez-Funez et al., 2000, Spradling, 1999.12.9, Spradling et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Parkinson's disease

modeled by park²⁵

(Whitworth et al., 2005)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

GstS1^k09303 mutants have no effect on climbing ability.

(Whitworth et al., 2005)

No obvious phenotype.

(Spradling et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

GstS1^k09303/GstS1[+] is an enhancer of abnormal locomotor behavior | adult stage phenotype of park²⁵

(Whitworth et al., 2005)

Phenotype Manifest In

Enhancer of

Statement

Reference

GstS1^k09303 is an enhancer of eye phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

GstS1^k09303 is an enhancer of retina phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The homozygous park²⁵ mutant climbing defect is enhanced when heterozygous with GstS1^k09303. GstS1^k09303 mutants have no effect on climbing ability in heterozygous park²⁵ mutants.

(Whitworth et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

10874

y¹ w^67c23; P{lacW}GstS1^k09303, l(2)k09303^k09303/CyO

Kyoto

102700

y¹ w^67c23 ; P{lacW}GstS1^k09303 / CyO

Notes on Origin

Discoverer

Separable from: l(2)k09303^k09303. The lethality of the "l(2)k09303" chromosome (caused by l(2)k09303^k09303) is separable from the P{lacW}GstS1^k09303 insertion.

(Spradling, 1999.12.9)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Gst2^k09303

(Singh et al., 2001, Fernandez-Funez et al., 2000)

GstS1^K9303

(Whitworth et al., 2005)

GstS1^k09303

n(2)k09303

(Spradling, 1999.12.9, Spradling et al., 1999)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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