FlyBase Allele Report: Dmel\αSnap[P2]

General Information

Symbol

Dmel\αSnap^P2

Species

D. melanogaster

Name

FlyBase ID

FBal0102587

Feature type

allele

Associated gene

Dmel\αSnap

Associated Insertion(s)

Carried in Construct

Also Known As

SNAP^P2

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Lukinova et al., 1999)

Progenitor genotype

Cytology

Description

Amino acid replacement: R292term.

(Babcock et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:20,315,542..20,315,542 [+]

Nucleotide change:

C20315542T

Reported nucleotide change:

C?T

Amino acid change:

R292term | alphaSnap-PA

Reported amino acid change:

R292term

(Babcock et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Kaltenbach et al., 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Lukinova et al., 1999)

lethal - all die before end of larval stage | recessive

(Babcock et al., 2004)

some die during larval stage | recessive

(Babcock et al., 2004)

Phenotype Manifest In

Detailed Description

Statement

Reference

Hemizygotes show early lethality.

(Lukinova et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

αSnap^P2 is a suppressor of visible phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Kaltenbach et al., 2007)

Phenotype Manifest In

Suppressor of

Statement

Reference

αSnap^P2 is a suppressor of eye phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Kaltenbach et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

αSnap^l65

(Babcock et al., 2004)

αSnap^M4

(Babcock et al., 2004)

αSnap^G8

(Babcock et al., 2004)

αSnap^I1

(Babcock et al., 2004)

αSnap^M3

(Babcock et al., 2004)

Rescued by

αSnap^P2 is rescued by αSnap^+t8.9

(Babcock et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

(Lukinova et al., 1999)

SNAP^P2

(Kaltenbach et al., 2007, Babcock et al., 2004)

Snap^P2

l(3)77ABc^P2

l(3)77Abc^P2

(Babcock et al., 2004)

αSnap^P2

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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