FlyBase Allele Report: Dmel\klar[glrs.Tag:MYC]

General Information

Symbol

Dmel\klar^glrs.Tag:MYC

Species

D. melanogaster

Name

FlyBase ID

FBal0102657

Feature type

allele

Associated gene

Dmel\klar

Associated Insertion(s)

Carried in Construct

P{glrs-klar.Myc}

Key Links

Transgenic product class

cDNA

(Mosley-Bishop et al., 1999)

wild_type

(Mosley-Bishop et al., 1999)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Mosley-Bishop et al., 1999)

wild_type

(Mosley-Bishop et al., 1999)

Mutagen

in vitro construct

(Mosley-Bishop et al., 1999)

Progenitor genotype

Carried in construct

P{glrs-klar.Myc}

Cytology

Description

150bp XbaI fragment containing the TATA box and transcription start of Hsp27 and a 200bp XbaI fragment containing five short gl-binding sites are fused to an klar cDNA tagged with Tag:MYC.

(Mosley-Bishop et al., 1999)

Allele components

Component

Use(s)

Encoded product / tool

klar

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye

(Mosley-Bishop et al., 1999)

eye photoreceptor cell

(Mosley-Bishop et al., 1999)

ommatidium

(Mosley-Bishop et al., 1999)

Detailed Description

Statement

Reference

Some of the P{glrs-klar.Myc} lines exhibit an eye phenotype when present in two copies A rough eye phenotype is seen. In the retina, facets are disorganised and far too few photoreceptors are seen.

(Mosley-Bishop et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

klar^glrs.Tag:MYC has eye phenotype, enhanceable by Lam⁸³

(Patterson et al., 2004)

klar^glrs.Tag:MYC has eye phenotype, enhanceable by Lam^A25

(Patterson et al., 2004)

klar^glrs.Tag:MYC has eye phenotype, enhanceable by Lam^Ari3

(Patterson et al., 2004)

klar^glrs.Tag:MYC has eye phenotype, enhanceable by Lam^K2

(Patterson et al., 2004)

klar^glrs.Tag:MYC has eye phenotype, enhanceable by Lam^Ari7

(Patterson et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

The following alleles enhance the rough eye phenotype of klar^{glrs.T:Hsap\MYC} mutants: Lam^Ari7, Lam^Ari3, Lam^A25, Lam^K2 and Lam⁸³.

(Patterson et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

klar^glrs.Tag:MYC partially rescues klar^marb-CD4

(Mosley-Bishop et al., 1999)

Comments

One copy of klar^{glrs.T:Hsap\MYC} almost completely rescues the homozygous klar^marb-CD4 eye phenotype. The ommatidia are nearly wildtype and the R-cell nuclei are apical. R-cell apical nuclear migration and cone cell migration are wild-type.

(Mosley-Bishop et al., 1999)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

klar^{glrs.T:Hsap\MYC}

klar^glrs.Tag:MYC

kls^{glrs.T:Hsap\MYC}

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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