Mutation is within the highly conserved C-terminal domain.
Amino acid replacement: P507L.
C20434943T
P507L | Psn-PA; P493L | Psn-PB; P474L | Psn-PC; P493L | Psn-PD; P507L | Psn-PE
P507L
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
Young (less than 10 days old) males heterozygous for PsnI2 do not show any defects in their courtship behavior or locomotor activity compared to wild-type. Their learning index during training with mated unreceptive female is also normal as is their immediate recall memory (assayed by measuring courtship behavior of a male which has just completed a training with a mated unreceptive female toward a receptive virgin female) and 60 min short-term memory (courtship of the trained male is assayed after a 60 min break).
30-day old males heterozygous for Psn46 also do not show any defects in the level or quality of naive courtship, locomotor activity, phototaxis or chemotaxis, however they display learning defects (fail to demonstrate the typical decrease in courtship activity when paired with an mated unreceptive female) as well as loss of short-term (60 min) memory is impaired (immediate recall memory is normal though).
Psn46/PsnW6 and Psn46/PsnW11 show early pupal lethality. The third instar larvae form a pupal case, but no adult structures develop. Mutant larvae show underdeveloped eye and wing discs. The eye imaginal disc fails to undergo proper neuronal differentiation. The wing imaginal disc is smaller with the most severe defects observed in the region that will give rise to the wing blade. The antenna and leg imaginal discs appear normal.
L. Pallanck and B. Ganetzky