FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Psn46
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General Information
Symbol
Dmel\Psn46
Species
D. melanogaster
Name
FlyBase ID
FBal0102925
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

Mutation is within the highly conserved C-terminal domain.

Amino acid replacement: P507L.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Nucleotide change:

C20434943T

Amino acid change:

P507L | Psn-PA; P493L | Psn-PB; P474L | Psn-PC; P493L | Psn-PD; P507L | Psn-PE

Reported amino acid change:

P507L

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Young (less than 10 days old) males heterozygous for PsnI2 do not show any defects in their courtship behavior or locomotor activity compared to wild-type. Their learning index during training with mated unreceptive female is also normal as is their immediate recall memory (assayed by measuring courtship behavior of a male which has just completed a training with a mated unreceptive female toward a receptive virgin female) and 60 min short-term memory (courtship of the trained male is assayed after a 60 min break).

30-day old males heterozygous for Psn46 also do not show any defects in the level or quality of naive courtship, locomotor activity, phototaxis or chemotaxis, however they display learning defects (fail to demonstrate the typical decrease in courtship activity when paired with an mated unreceptive female) as well as loss of short-term (60 min) memory is impaired (immediate recall memory is normal though).

Psn46/PsnW6 and Psn46/PsnW11 show early pupal lethality. The third instar larvae form a pupal case, but no adult structures develop. Mutant larvae show underdeveloped eye and wing discs. The eye imaginal disc fails to undergo proper neuronal differentiation. The wing imaginal disc is smaller with the most severe defects observed in the region that will give rise to the wing blade. The antenna and leg imaginal discs appear normal.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

L. Pallanck and B. Ganetzky

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)