FlyBase Allele Report: Dmel\Diap1[9]

General Information

Symbol

Dmel\Diap1⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0103509

Feature type

allele

Associated gene

Dmel\Diap1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Lisi et al., 2000)

Mutagen

ethyl methanesulfonate

(Lisi et al., 2000)

Progenitor genotype

Diap1^SL

(Lisi et al., 2000)

Cytology

Description

Mutation falls in the BIR1 domain. Retains the V85M mutation in BIR1 of progenitor Diap1^SL.

(Lisi et al., 2000)

Amino acid replacement: P55L.

(Lisi et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:16,039,825..16,039,825 [-]

Nucleotide change:

C16039825T

Amino acid change:

Reported amino acid change:

P55L

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. Retains the V85M mutation in BIR1 of progenitor Diap1^SL.

(Lisi et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Lisi et al., 2000)

Phenotype Manifest In

embryo

(Lisi et al., 2000)

Detailed Description

Statement

Reference

Embryos show increased cell death as assessed by TUNEL staining. The onset of this apoptosis appears several hours after development arrests.

(Lisi et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Diap1⁹ is an enhancer of abnormal cell death phenotype of hid^GMR.PG

(Lisi et al., 2000)

Diap1⁹ is an enhancer of abnormal cell death phenotype of grim^GMR.PC

(Lisi et al., 2000)

Diap1⁹ is an enhancer of abnormal cell death phenotype of rpr^GMR.PW

(Lisi et al., 2000)

Phenotype Manifest In

Enhancer of

Statement

Reference

Diap1⁹ is an enhancer of eye phenotype of hid^GMR.PG

(Lisi et al., 2000)

Diap1⁹ is an enhancer of eye phenotype of grim^GMR.PC

(Lisi et al., 2000)

Diap1⁹ is an enhancer of eye phenotype of rpr^GMR.PW

(Lisi et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Diap1^unspecified

(Lisi et al., 2000)

Comments

Fails to complement other lethal th alleles for lethality.

(Lisi et al., 2000)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Revertant.

(Lisi et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Diap1⁹

th⁹

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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