FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\γTub23CA6-2
Open Close
General Information
Symbol
Dmel\γTub23CA6-2
Species
D. melanogaster
Name
FlyBase ID
FBal0103687
Feature type
allele
Associated gene
Dmel\γTub23C
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Eeken, 2000.2.29)
Progenitor genotype
Cytology
Description

Amino acid replacement: S233F.

(Vázquez et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:2,973,874..2,973,874 [+]
Nucleotide change:

C2973874T

Amino acid change:

S233F | gammaTub23C-PA

Reported amino acid change:

S233F

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Vázquez et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      2% of γTub23CA6-2/Df(2L)3G animals survive to eclosion, but all quickly become stuck in the food medium.

      3% of γTub23CA6-2/γTub23CA15-2 animals survive to eclosion, but all quickly become stuck in the food medium.

      6% of γTub23CA6-2/γTub23CPl-2 animals survive to eclosion, but all quickly become stuck in the food medium.

      65% of γTub23CA14-9/γTub23CA6-2 animals survive to eclosion.

      (Vázquez et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      NOT suppressed by
      Statement
      Reference

      γTub23CA6-2/Df(2L)JS17 has lethal phenotype, non-suppressible by Grip91su(Pl)

      (Vázquez et al., 2008)

      Df(2L)3G/γTub23CA6-2 has lethal phenotype, non-suppressible by Grip91su(Pl)

      (Vázquez et al., 2008)

      γTub23CA6-2/γTub23CA15-2 has lethal phenotype, non-suppressible by Grip91su(Pl)

      (Vázquez et al., 2008)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The reduced viability of γTub23CA14-9/γTub23CA6-2 flies is not further reduced by brm2/+.

      (Vázquez et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Allelic series (in order of decreasing activity): γTub23CA14-9 > γTub23CA6-2 > γTub23CA15-2 = Df(2L)JS17 = Df(2L)3G > γTub23CPl-2.

      (Vázquez et al., 2008)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      l(2)23CeA6-2
      (Vázquez et al., 2008)
      γTub23CA6-2
      (Vázquez et al., 2008)
      γTubulin23CA6-2
      (Segura et al., 2025)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)