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General Information
Symbol
Dmel\chinmoM33
Species
D. melanogaster
Name
FlyBase ID
FBal0103704
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

T1694367A

Amino acid change:

F88I | chinmo-PA; F88I | chinmo-PD; F88I | chinmo-PE; F88I | chinmo-PF; F88I | chinmo-PG; F88I | chinmo-PH

Reported amino acid change:

F88I

Comment:

Site of nucleotide substitution inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

chinmoM33 encodes a missense mutation (F88I) in the BTB domain.

Amino acid replacement: F88I.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

chinmoM33/chinmo1, chinmoM33/Df(2L)S2, chinmoM33/Df(2L)ast2, chinmoM33/Df(2L)dp-79b, chinmoM33/Df(2L)Exel6005, chinmoM33/Df(2L)ED7762, chinmoM33/Df(2L)BSC480, or chinmoM33/Df(2L)BSC521 mutants are lethal.

chinmoM33/chinmoM33 mutant somatic cyst stem cell clones are lost from the adult testis stem cell niche and testes do not exhibit any signs of sex transformation.

chinmoST/chinmoM33 or chinmoKG05386/chinmoM33 mutant males exhibit somatic cells with a follicle cell-like phenotype.

Few escapers with eye-antennal disc chinmoM33 clones (in the Minute background) exhibit excess head cuticle, reduction of the eye field, partial or complete loss of antennal segments when compared to controls.

At 2 days post-clone induction (pci), chinmoM33 germline stem cell (GSC, Vasa staining) clones are in contact with the Hub (a group of somatic cells in testis) and cyst stem cell (CySC, Zfh1 or Tj staining) clones envelope germ line cells; at 7 days pci there are numerous GSC clones still in contact with the Hub while there are not any CySc clones but there are Tj+ somatic clones outside of the Hub when compared to control flip-out clones.

There appear to be far more projections of the pioneer α/β type in chinmoM33 mutant neuroblast clones, with qualitatively fewer γ type neurons.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

M. Postner

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)