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General Information
Symbol
Dmel\chinmoST
Species
D. melanogaster
Name
Sex Transformation
FlyBase ID
FBal0320047
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

10bp deletion in the 5'UTR.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

chinmoST/chinmoST mutant males are fertile and exhibit normal testis morphology at 0-1 days old, but display a progressive change in testis morphology, wherein they start to exhibit somatic cells with a follicle cell-like phenotype. At 2-3 days, aggregates of epithelial somatic cells appear adjacent to the hub. Over time, somatic cell aggregates acquire additional cells and extend away from the testis apex; older differentiating germ cells and cyst cells are displaced toward the basal end of testis. In 7-9-day old males, somatic cell aggregates adjacent to the hub remain and a monolayer of columnar epithelial cells lines the testis periphery, resembling ovarian follicle cells; germ cells are restricted to the lumen of the tissue and are arrested at the spermatogonial stage. The arrangement of somatic cells resembles somatic follicle cells within the Drosophila ovary. By 2-3 weeks, arrested germ cells are observed to degenerate. Somatic cells resembling stalk cells become apparent in older chinmoST/chinmoST testes.

chinmoST/chinmoKG05386, chinmoST/chinmoM33, chinmoST/chinmo1, chinmoST/Df(2L)S2, chinmoST/Df(2L)ast2, chinmoST/Df(2L)dp-79b, chinmoST/Df(2L)Exel6005, chinmoST/Df(2L)ED7762, chinmoST/Df(2L)BSC480, or chinmoST/Df(2L)BSC521 mutant males exhibit somatic cells with a follicle cell-like phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of chinmoScer\UAS.fl under the control of Scer\GAL4C587 rescues the somatic cell defects of chinmoST/chinmoST mutant testes.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Sex Transformation
Secondary FlyBase IDs
    References (2)