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General Information
Symbol
Dmel\chinmoUAS.fl
Species
D. melanogaster
Name
FlyBase ID
FBal0197457
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-chinmo, UAS-chinmoFL, UAS-5'UTR-chinmo-3'UTR
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of full length chinmo coding and UTR sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of chinmoUAS.fl under the control of Scer\GAL4A3.eya leads to following changes in the testes: an increase in the number of undifferentiated germ and cyst cells throughout the testes (bright DAPI labelled cells, although with normal germ cell ensheathment (DE-cad staining)); most somatic cells show characteristics of cyst stem cells/early cyst cells exhibiting high levels of Tj and Zfh1, but low levels of Eya; most germ cells retain germline stem cells/gonioblasts characteristics, with germ cells residing far from the Hub exhibit high esg levels and individual cells/pairs of cells containing fusomes and not expressing Bam; and excess germ cells and somatic cells often undergo mitosis as single cells when compared to controls.

Expression of chinmoUAS.fl under the control of Scer\GAL4VP16.nos.UTR does not lead to expansion of germline stem cells (Vasa staining) or cyst stem cells (Tj staining) when compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of chinmoScer\UAS.fl under the control of Scer\GAL4C587 rescues the somatic cell defects of chinmoST/chinmoST mutant testes.

Expression of chinmoScer\UAS.fl, under the control of Scer\GAL4OK107 grossly rescues the phenotypes characteristic of chinmo1 mutant mushroom body neuroblast clones.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
chinmoScer\UAS.fl
chinmoUAS.fl
Name Synonyms
Secondary FlyBase IDs
    References (9)