FlyBase Allele Report: Dmel\eya[A188]

General Information

Symbol

Dmel\eya^A188

Species

D. melanogaster

Name

FlyBase ID

FBal0103874

Feature type

allele

Associated gene

Dmel\eya

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

X ray

(Rebay et al., 2000)

ethyl methanesulfonate

(Rebay et al., 2000)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage (with eya²)

(Xiong et al., 2009)

lethal | recessive

(Rebay et al., 2000)

Phenotype Manifest In

lamina | third instar larval stage (with eya²)

(Xiong et al., 2009)

Detailed Description

Statement

Reference

The embryonic CNS of eya^A188 homozygotes is indistinguishable from wild type.

Instead of forming an even plexus of growth cones at the lamina, photoreceptor axons in eya^A188/eya² larvae fasciculate aberrantly to produce an irregular pattern of gaps and thickenings in the lamina, with a significant percentage of axon bundles failing to terminate properly at the lamina.

(Xiong et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

eya^A188/eya^A188 is an enhancer of abnormal neuroanatomy | embryonic stage phenotype of Abl²

(Xiong et al., 2009)

eya[+]/eya^A188 is an enhancer of partially lethal - majority live phenotype of Abl²/Abl¹

(Xiong et al., 2009)

eya[+]/eya^A188 is an enhancer of abnormal neuroanatomy | third instar larval stage phenotype of Abl²/Abl¹

(Xiong et al., 2009)

eya[+]/eya^A188 is an enhancer of abnormal neuroanatomy | embryonic stage phenotype of Abl²

(Xiong et al., 2009)

Other

Statement

Reference

Abl², eya^A188/eya² has lethal - all die before end of larval stage phenotype

(Xiong et al., 2009)

Abl³/Abl², eya^A188/eya² has lethal - all die before end of larval stage phenotype

(Xiong et al., 2009)

Raf¹², eya^A188 has lethal phenotype

(Rebay et al., 2000)

Raf¹², eya^A188 has lethal | dominant phenotype

(Rebay et al., 2000)

Phenotype Manifest In

Enhancer of

Statement

Reference

eya[+]/eya^A188 is an enhancer of lamina | third instar larval stage phenotype of Abl²/Abl¹

(Xiong et al., 2009)

eya[+]/eya^A188 is an enhancer of larval ventral nerve cord | embryonic stage phenotype of Abl²

(Xiong et al., 2009)

eya^A188/eya^A188 is an enhancer of larval ventral nerve cord | embryonic stage phenotype of Abl²

(Xiong et al., 2009)

eya^A188 is an enhancer of eye phenotype of Ras85D^N17.sev

(Rebay et al., 2000)

eya^A188 is an enhancer of eye phenotype of aop^S2382

(Rebay et al., 2000)

eya^A188 is an enhancer of eye phenotype of aop^ACT.sev

(Rebay et al., 2000)

eya^A188 is an enhancer of eye phenotype of aop^ACT.GMR

(Rebay et al., 2000)

Suppressor of

Statement

Reference

eya^A188 is a suppressor of eye phenotype of Ras85D^V12.sev

(Rebay et al., 2000)

Other

Statement

Reference

Abl², eya[+]/eya^A188 has larval ventral nerve cord commissure | embryonic stage phenotype

(Xiong et al., 2009)

Abl², eya^A188 has larval ventral nerve cord commissure | embryonic stage phenotype

(Xiong et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

eya^A188/+ reduces the hatch rate of Abl¹/Abl² embryos from 90% to 20%.

Abl², eya^A188/+ embryos have discontinuities along the longitudinal axon bundles with 20% of commissures lost or defective. Abl², eya^A188 embryos show severe disruptions in the longitudinal tracts and 77% of commissures are lost.

The embryonic CNS of eya^A188, Abl²/+ is indistinguishable from wild type.

eya^A188/+ enhances the Abl¹/Abl² mistargeting phenotype, resulting in a highly disorganized lamina plexus.

(Xiong et al., 2009)

Effect on aop^S2382 and Ras85D^N17.sev is mild. Effect on aop^ACT.GMR, aop^ACT.sev and Ras85D^V12.sev is moderate. Lethal in combination with phl¹² at 18^oC.

(Rebay et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

eya^G130

(Rebay et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

"X ray" was stated as tentative. "ethyl methanesulfonate" was stated as tentative.

(Rebay et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

cli^A188

eya^A188

(Davis and Rebay, 2017, Xiong et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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