FlyBase Allele Report: Dmel\aop[ACT.sev]

General Information

Symbol

Dmel\aop^ACT.sev

Species

D. melanogaster

Name

activated

FlyBase ID

FBal0042853

Feature type

allele

Associated gene

Dmel\aop

Associated Insertion(s)

Carried in Construct

P{sev-yan^ACT}

Also Known As

sev-yan^ACT

Key Links

Transgenic product class

missense_variant

(Rebay and Rubin, 1995)

polypeptide_post_translational_processing_variant

(Rebay and Rubin, 1995)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Rebay and Rubin, 1995)

polypeptide_post_translational_processing_variant

(Rebay and Rubin, 1995)

Mutagen

in vitro construct

(Rebay and Rubin, 1995)

Progenitor genotype

aop^WT.sev

(Rebay and Rubin, 1995)

Carried in construct

P{sev-yan^ACT}

Cytology

Description

Construct: Phosphoacceptor residues at the eight consensus sites within the coding region are replaced with a nonphosphorylatable amino acid, alanine. Expression is driven by an sev promoter.

(Rebay and Rubin, 1995)

Allele components

Component

Use(s)

Regulatory region(s)

sev

Encoded product / tool

aop

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | adult stage

(Wu et al., 2020)

visible

(Vivekanand et al., 2004, Tootle et al., 2003, Rebay et al., 2000)

visible | adult stage

(Wu et al., 2020)

Phenotype Manifest In

Detailed Description

Statement

Reference

aop^ACT.sev mutants exhibit a rough eye phenotype.

(Wang et al., 2008)

Flies carrying aop^ACT.sev have a rough eye phenotype.

(Vivekanand et al., 2004, Tootle et al., 2003)

Mutants show reduced number of R7 photoreceptors.

(Bai et al., 2001)

Flies have rough eyes characterized by the loss of the R3, R4 and R7 photoreceptor neurons and the nonneuronal cone cells.

(Rebay et al., 2000)

Eyes are slightly smaller than wild type with a rough appearance, photoreceptors R3, R4 and R7 fail to develop. Also an increase in cell death in eye tissue.

(Rebay and Rubin, 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

aop^ACT.sev has decreased cell number | adult stage phenotype, enhanceable by pnt^p2

(Wu et al., 2020)

aop^ACT.sev has visible | adult stage phenotype, enhanceable by pnt^p2

(Wu et al., 2020)

aop^ACT.sev has decreased cell number | adult stage phenotype, enhanceable by pnt^p3

(Wu et al., 2020)

aop^ACT.sev has visible | adult stage phenotype, enhanceable by pnt^p3

(Wu et al., 2020)

aop^ACT.sev has decreased cell number | adult stage phenotype, enhanceable by pnt^p2p3

(Wu et al., 2020)

aop^ACT.sev has visible phenotype, enhanceable by edl^UAS.Tag:MYC/Scer\GAL4^hs.2sev

(Vivekanand et al., 2004)

aop^ACT.sev has visible phenotype, enhanceable by edl[+]/edl^k06602

(Vivekanand et al., 2004)

aop^ACT.sev has visible phenotype, enhanceable by edl^unspecified

(Tootle et al., 2003)

Enhancer of

Statement

Reference

aop^ACT.sev is an enhancer of visible phenotype of lz^ts1

(Behan et al., 2002)

Other

Statement

Reference

aop^ACT.sev, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

aop^ACT.sev has eye photoreceptor cell | adult stage | decreased number phenotype, enhanceable by pnt^p2

(Wu et al., 2020)

aop^ACT.sev has eye phenotype, enhanceable by pnt^p2

(Wu et al., 2020)

aop^ACT.sev has eye photoreceptor cell | adult stage | decreased number phenotype, enhanceable by pnt^p3

(Wu et al., 2020)

aop^ACT.sev has eye phenotype, enhanceable by pnt^p3

(Wu et al., 2020)

aop^ACT.sev has eye photoreceptor cell | adult stage | decreased number phenotype, enhanceable by pnt^p2p3

(Wu et al., 2020)

aop^ACT.sev has eye phenotype, enhanceable by edl^UAS.Tag:MYC/Scer\GAL4^hs.2sev

(Vivekanand et al., 2004)

aop^ACT.sev has eye phenotype, enhanceable by edl[+]/edl^k06602

(Vivekanand et al., 2004)

aop^ACT.sev has eye phenotype, enhanceable by edl^unspecified

(Tootle et al., 2003)

aop^ACT.sev has ommatidium phenotype, enhanceable by edl^unspecified

(Tootle et al., 2003)

aop^ACT.sev has eye phenotype, enhanceable by EY2-5^AH425

(Rebay et al., 2000)

aop^ACT.sev has eye phenotype, enhanceable by EY2-6^AC403

(Rebay et al., 2000)

aop^ACT.sev has eye phenotype, enhanceable by EY2-6^AQR618

(Rebay et al., 2000)

aop^ACT.sev has eye phenotype, enhanceable by EY3-4^x1S805

(Rebay et al., 2000)

aop^ACT.sev has eye phenotype, enhanceable by EY3-4^xII790

(Rebay et al., 2000)

aop^ACT.sev has eye phenotype, enhanceable by EY3-5^xKR845

(Rebay et al., 2000)

aop^ACT.sev has eye phenotype, enhanceable by EY3-5^xZB970

(Rebay et al., 2000)

aop^ACT.sev has eye phenotype, enhanceable by S^BA651

(Rebay et al., 2000)

aop^ACT.sev has eye phenotype, enhanceable by S^U132

(Rebay et al., 2000)

aop^ACT.sev has eye phenotype, enhanceable by Sos^D120

(Rebay et al., 2000)

aop^ACT.sev has eye phenotype, enhanceable by Sos^xB10

(Rebay et al., 2000)

aop^ACT.sev has eye phenotype, enhanceable by eya^A188

(Rebay et al., 2000)

aop^ACT.sev has eye phenotype, enhanceable by eya^G130

(Rebay et al., 2000)

aop^ACT.sev has eye phenotype, enhanceable by retn^B142

(Rebay et al., 2000)

aop^ACT.sev has eye phenotype, enhanceable by retn^x1N793

(Rebay et al., 2000)

aop^ACT.sev has eye phenotype, enhanceable by pnt^AF397

(Rebay et al., 2000)

aop^ACT.sev has eye phenotype, enhanceable by pnt^AP553

(Rebay et al., 2000)

aop^ACT.sev has eye phenotype, enhanceable by rl^A0648

(Rebay et al., 2000)

aop^ACT.sev has eye phenotype, enhanceable by spen^AH393

(Rebay et al., 2000)

aop^ACT.sev has eye phenotype, enhanceable by spen^BU720

(Rebay et al., 2000)

aop^ACT.sev has phenotype, enhanceable by Sos^EY2-3

(Chen et al., 1999)

NOT Enhanced by

Statement

Reference

aop^ACT.sev has phenotype, non-enhanceable by lilli^XS407

(Tang et al., 2001)

aop^ACT.sev has phenotype, non-enhanceable by lilli^XS575

(Tang et al., 2001)

aop^ACT.sev has phenotype, non-enhanceable by lilli^s35

(Tang et al., 2001)

aop^ACT.sev has phenotype, non-enhanceable by EY2-5^DW1080

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-enhanceable by EY2-8^xCB204

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-enhanceable by EY3-2^xAZ145

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-enhanceable by EY3-2^xCF301

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-enhanceable by EY3-2^xDF411

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-enhanceable by EY3-3^xBE183

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-enhanceable by EY3-3^xF6

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-enhanceable by Su(Tpl)^DI998

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-enhanceable by Su(Tpl)^EZ1217

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-enhanceable by lilli^DE884

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-enhanceable by lilli^DR999

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-enhanceable by Sin3A^CY886

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-enhanceable by Sin3A^DW1046

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-enhanceable by gl^DZ1053

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-enhanceable by gl^ER1085

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-enhanceable by EY2-8^EP1160

(Rebay et al., 2000)

Suppressed by

Statement

Reference

aop^ACT.sev has eye phenotype, suppressible by aop^ACT.sev

(Wang et al., 2008)

aop^ACT.sev has photoreceptor cell R7 phenotype, suppressible by ed^slH8/ed^1X5

(Bai et al., 2001)

aop^ACT.sev has ommatidium phenotype, suppressible by ed^slH8/ed^1X5

(Bai et al., 2001)

aop^ACT.sev has eye phenotype, suppressible by Taf4^AG456

(Rebay et al., 2000)

aop^ACT.sev has eye phenotype, suppressible by Taf4^I53

(Rebay et al., 2000)

aop^ACT.sev has eye phenotype, suppressible by stg^D115

(Rebay et al., 2000)

aop^ACT.sev has eye phenotype, suppressible by stg^DD937

(Rebay et al., 2000)

NOT suppressed by

Statement

Reference

aop^ACT.sev has phenotype, non-suppressible by lilli^XS407

(Tang et al., 2001)

aop^ACT.sev has phenotype, non-suppressible by lilli^s35

(Tang et al., 2001)

aop^ACT.sev has phenotype, non-suppressible by lilli^XS575

(Tang et al., 2001)

aop^ACT.sev has phenotype, non-suppressible by EY3-3^xF6

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-suppressible by Su(Tpl)^DI998

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-suppressible by Su(Tpl)^EZ1217

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-suppressible by lilli^DE884

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-suppressible by lilli^DR999

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-suppressible by Sin3A^CY886

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-suppressible by Sin3A^DW1046

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-suppressible by gl^DZ1053

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-suppressible by gl^ER1085

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-suppressible by EY2-5^DW1080

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-suppressible by EY2-8^EP1160

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-suppressible by EY2-8^xCB204

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-suppressible by EY3-2^xAZ145

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-suppressible by EY3-2^xCF301

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-suppressible by EY3-2^xDF411

(Rebay et al., 2000)

aop^ACT.sev has phenotype, non-suppressible by EY3-3^xBE183

(Rebay et al., 2000)

Enhancer of

Statement

Reference

aop^ACT.sev is an enhancer of eye phenotype of lz^ts1

(Behan et al., 2002)

Suppressor of

Statement

Reference

aop^ACT.sev is a suppressor of eye phenotype of aop^ACT.sev

(Wang et al., 2008)

Other

Statement

Reference

aop^ACT.sev, rl^AL528 has eye phenotype

(Rebay et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

A Cbl^K26 heterozygous background rescues the rough eye phenotype found in aop^ACT.sev mutants.

(Wang et al., 2008)

The rough eye phenotype caused by aop^ACT.sev is enhanced if the flies also carry edl^k06602/+. The rough eye phenotype caused by aop^ACT.sev is enhanced by expression of edl^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^hs.2sev.

(Vivekanand et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

5791

w^*; P{sev-yan^ACT}IVb

Notes on Origin

Discoverer

Comments

Dominant activated form of aop.

(Kauffmann et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Sev-Yan^ACT

(Chen et al., 1999)

aop^ACT.sev

Name Synonyms

activated

(Rebay and Rubin, 1995)

Secondary FlyBase IDs

References (14)

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