Expression of DScer\UAS.cMa under the control of Scer\GAL4GMR.PF results in a moderate eye roughening, with a disorganisation of ommatidia and loss of most mechanosensory bristles. There is a slight loss of pigmentation.
When DScer\UAS.cMa is driven by Scer\GAL4dpp.blk1 at 25oC, animals survive to the pharate adult stage but fail to eclose. These flies exhibit multiple morphological disruptions of eyes, antennae, wings legs and bristles. The arista region of the antenna is generally lacking and replaced by a thick cuticular structure. Some animals exhibit arista-to-tarsal transformation. More proximal regions of the antennae are normal. Legs are severely truncated, as tarsal segments 2-4 are generally fused or missing. In addition both tarsal and tibial regions often exhibit ventralisation, and in some animals, a small distal leg segment is also detected. Eye imaginal discs are greatly reduced and lack a morphogenetic furrow. Flies exhibit moderate to severe loss of eye tissues, with many individuals exhibiting a complete absence of ommatidia. When DScer\UAS.cMa is driven by Scer\GAL430A, flies are viable, but exhibit reduced aristae that are compressed along the proximal/distal axis. The main aristal branch is severely shortened and the side branches are also stunted, though not reduced in number. When driven by Scer\GAL4GMR.PF, flies exhibit a reduction and disorganisation of ommatidia and mechanosensory bristles. At higher doses, a total absence of ommatidia and mechanosensory bristles is seen, replaced by necrotic cell masses. When driven by Scer\GAL4Dll-md23, complete prepupal lethality is seen.