FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ttktwp
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General Information
Symbol
Dmel\ttktwp
Species
D. melanogaster
Name
twin peaks
FlyBase ID
FBal0104411
Feature type
allele
Associated gene
Dmel\ttk
Associated Insertion(s)
P{PZ}ttktwp
Carried in Construct
Also Known As
ttktwk
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Berg, 2000.3.7)
Progenitor genotype
Associated Insertion(s)
P{PZ}ttktwp
Cytology
Description

The P{PZ} insertion is within exon 1a.

(French et al., 2003)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Eggs from ttktwp germline clones have normal appendage formation at S14.

      Eggs from ttktwp follicular epithelial clones have short appendages at S14.

      At S13, dorsal appendage forming follicle cells do not re-expand apical surfaces and shorten lateral surfaces in ttktwp mutants. Nevertheless the basal cell surfaces migrate anteriorly and thin, elongated cells form, as seen in controls.

      (Boyle and Berg, 2009)

      Eggs chambers from homozygous mutant mothers, initiate but fail to complete, dorsal appendage morphogenesis. While two appendages initially form with proper spacing, these appendages fail to extend to their normal length. Up to stage 11 egg chambers have a normal morphology. In stage 12 mutant egg chambers, chorion proteins are not deposited normally however follicle cells do initiate morphogenesis. the degree of cell movement is similar to wild-type at this stage. Stage 13 mutant egg chambers display a severe defect in follicle cell movement, and dorsal appendages have not extended past the degenerating nurse cells at the anterior end of the egg chamber. Eggs from mutant mothers are also abnormally short and round, with a thin and fragile chorion. Eggs chambers from hemizygous (over Df(3R)awd-KRB), and ttktwp/ttk1e11 mutant mothers, initiate but fail to complete, dorsal appendage morphogenesis. ttktwp/ttk1 eggs exhibit a weak dorsal appendage phenotype, with 12% show some defect.

      (French et al., 2003)

      Egg chambers have rudimentary nubs in place of dorsal appendages.

      (French and Berg, 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      ttk[+]/ttktwp is an enhancer of dorsal appendage phenotype of PaxNIG.18061R, Scer\GAL4Vm26Aa.F

      (Peters et al., 2013)

      ttk[+]/ttktwp is an enhancer of dorsal appendage phenotype of PaxNIG.18061R, Scer\GAL4CY2

      (Peters et al., 2013)

      ttk[+]/ttktwp is an enhancer of dorsal appendage phenotype of Cp16KK112398, Scer\GAL4CY2

      (Peters et al., 2013)

      ttk[+]/ttktwp is an enhancer of dorsal appendage phenotype of Scer\GAL4Vm26Aa.F, mirrJF02196

      (Peters et al., 2013)

      ttk[+]/ttktwp is an enhancer of dorsal appendage phenotype of Scer\GAL4CY2, lamaKK101851

      (Peters et al., 2013)

      ttk[+]/ttktwp is an enhancer of dorsal appendage phenotype of Scer\GAL4Vm26Aa.F, shiKK101444

      (Peters et al., 2013)

      ttk[+]/ttktwp is an enhancer of dorsal appendage phenotype of Scer\GAL4CY2, shiKK101444

      (Peters et al., 2013)

      ttk[+]/ttktwp is an enhancer of dorsal appendage phenotype of Rac2GD17536, Scer\GAL4Vm26Aa.F

      (Peters et al., 2013)

      ttk[+]/ttktwp is an enhancer of dorsal appendage phenotype of Rac2GD17536, Scer\GAL4CY2

      (Peters et al., 2013)

      ttk[+]/ttktwp is an enhancer of dorsal appendage phenotype of Scer\GAL4Vm26Aa.F, kat80KK100477

      (Peters et al., 2013)

      ttk[+]/ttktwp is an enhancer of dorsal appendage phenotype of Scer\GAL4CY2, kat80KK100477

      (Peters et al., 2013)

      ttk[+]/ttktwp is an enhancer of dorsal appendage phenotype of Cp16KK112398, Scer\GAL4Vm26Aa.F

      (Peters et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The severity of the dorsal appendage defects caused by expression of mirrJF02196 under the control of Scer\GAL4Vm26Aa.F is enhanced by ttktwp/+.

      The severity of the dorsal appendage defects caused by expression of PaxNIG.18061R under the control of either Scer\GAL4Vm26Aa.F or Scer\GAL4CY2 is enhanced by ttktwp/+.

      The severity of the dorsal appendage defect caused by expression of lamaKK101851 under the control of Scer\GAL4CY2 is enhanced by ttktwp/+.

      The severity of the dorsal appendage defects caused by expression of shiKK101444 under the control of either Scer\GAL4Vm26Aa.F or Scer\GAL4CY2 is enhanced by ttktwp/+.

      The severity of the dorsal appendage defects caused by expression of Rac2GD17536 under the control of either Scer\GAL4Vm26Aa.F or Scer\GAL4CY2 is enhanced by ttktwp/+.

      The severity of the dorsal appendage defects caused by expression of kat80KK100477 under the control of either Scer\GAL4Vm26Aa.F or Scer\GAL4CY2 is enhanced by ttktwp/+.

      The severity of the dorsal appendage defects caused by expression of Cp16KK112398 under the control of either Scer\GAL4Vm26Aa.F or Scer\GAL4CY2 is enhanced by ttktwp/+.

      (Peters et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      ttk1

      (French et al., 2003)
      Fails to complement

      ttk1e11

      (French et al., 2003)
      Partially rescued by

      ttktwp/ttk1e11 is partially rescued by ttkp69.UAS/Scer\GAL4hs.PB

      (French et al., 2003)
      Not rescued by

      ttktwp/ttk1e11 is not rescued by ttkp88.UAS/Scer\GAL4hs.PB

      (French et al., 2003)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The phenotype is reverted by excision of the P{PZ} element.

      (French et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      Reported As
      Symbol Synonym
      fs(3)07223
      (Berg, 2000.3.7)
      ttktwk
      (Peters et al., 2013, Boyle and Berg, 2009, Boyle and Berg, 2007, French et al., 2003, French et al., 2003, French et al., 2001)
      ttktwp
      ttk[twk]
      (Boyle and Berg, 2006)
      twk
      (French et al., 2003)
      Name Synonyms
      tramtrack<up>twin peaks</up>
      (Boyle and Berg, 2007)
      twin peaks
      (French and Berg, 2000)
      Secondary FlyBase IDs
        References (10)