FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\slmbcrd
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General Information
Symbol
Dmel\slmbcrd
Species
D. melanogaster
Name
FlyBase ID
FBal0104425
Feature type
allele
Associated gene
Dmel\slmb
Associated Insertion(s)
P{lacW}slmbcrd
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Wojcik and Hays, 2000)
Mutagen
P-element activity
(Wojcik et al., 2000)
Progenitor genotype
Associated Insertion(s)
P{lacW}slmbcrd
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Affected cells have additional centrosomes and mitotic defects.

      (Wojcik and Hays, 2000)

      The majority of hemizygous mutant neuroblasts exhibit an excessive number of centrosomes. Diploid cells are observed that contain more than two and as many as seventeen centrosomes. Polyploid giant neuroblasts are also observed in mutant brain discs and they contain far greater numbers of centrosomes than predicted by failure in cleavage alone. 74% of those cells with abnormal numbers of centrosomes have even numbers of centrosomes. Despite such aberrant centrosomes, the spindles remain bipolar. The number of S phase cells in mutants is also decreased.

      (Wojcik et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Lethality is revertable by excision of the P{lacW} insertion.

      (Wojcik et al., 2000)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      slimbcrd
      (Wojcik and Hays, 2000, Wojcik et al., 2000)
      slmbcrd
      Name Synonyms
      slimbcrd
      (Wojcik et al., 2000)
      Secondary FlyBase IDs
        References (4)